普洱茶对α-葡萄糖苷酶和α-淀粉酶的抑制作用：系统评价。
Inhibitory effects of pu-erh tea on alpha glucosidase and alpha amylase: a systemic review.
机构信息
Department of Healthcare Administration, Asia University, Taiwan, Taiwan.
Department of Oral Hygiene, College of Dental Medicine, Kaohsiung Medical University, Taichung, Taiwan.
出版信息
Nutr Diabetes. 2019 Aug 27;9(1):23. doi: 10.1038/s41387-019-0092-y.
OBJECTIVE
Pu-erh tea was presumed to have anti-hyperglycemic effects via inhibition on alpha-amylase and alpha-glucosidase. However, no integerated literatures were published to substantiate such presumption.
METHODS
Current study adopted systemic review method to validate inhibitory effects on alpha amylase and alpha-glucosidase. Five English databases (PubMed, EBSCO, SCOPUS, Cochrane Library, Web of Science) and three Chinese ones (Airti Library, CNKI Library, and Google Scholar) were searched up to 22 March 2018 for eligible literatures, using keywords of Pu-erh, Pu'er, alpha-amylase or alpha-glucosidase.
RESULTS
Six studies exploring inhibitory effects on alpha-glucosidase and seven on alpha-amylase were included for systemic review. Though results showed pu-erh tea has significant inhibitory effects on alpha-amylase and alpha-glucosidase, high heterogeneity was detected among studies included.
CONCLUSIONS
High heterogeneity may be due to complex alterations of chemicals under different degrees of fermentation. More future studies are required to further identify principal bioactive component(s) at work.
目的
普洱茶被认为具有降血糖作用，通过抑制α-淀粉酶和α-葡萄糖苷酶。然而，没有整合文献来证实这种假设。
方法
本研究采用系统评价方法验证对α-淀粉酶和α-葡萄糖苷酶的抑制作用。检索了 5 个英文数据库（PubMed、EBSCO、SCOPUS、Cochrane Library、Web of Science）和 3 个中文数据库（Airti Library、CNKI Library 和 Google Scholar），截至 2018 年 3 月 22 日，使用了普洱茶、普耳、α-淀粉酶或α-葡萄糖苷酶等关键词，以查找合格文献。
结果
纳入了 6 项研究α-葡萄糖苷酶抑制作用和 7 项α-淀粉酶抑制作用的系统评价。尽管结果表明普洱茶对α-淀粉酶和α-葡萄糖苷酶有显著的抑制作用，但纳入的研究存在高度异质性。
结论
高度异质性可能是由于在不同发酵程度下化学物质的复杂变化所致。需要进一步的研究来确定起作用的主要生物活性成分。
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