Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.
Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
Adv Exp Med Biol. 2019;1152:271-281. doi: 10.1007/978-3-030-20301-6_14.
Rapidly emerging ground-breaking discoveries have provided near to complete resolution of breast cancer signaling landscape and scientists have mapped the knowledge gaps associated with proteins encoded by the human genome. Based on the insights gleaned from decades of research, it seems clear that ligands transmit distinct information through specific receptors that is processed into characteristically unique biological outputs. Advances in imaging, structural biology, proteomics and genome editing have helped us to gain new insights into JAK-STAT signaling and how alterations in this pathway contributed to development of breast cancer and metastatic spread. Data obtained through high-throughput technologies has started to shed light on signal-transducer complexes formed during JAK-STAT signaling. Pharmacologists and molecular biologists are focusing on the strategies to therapeutically target this pathway to overcome drug resistance associated with breast cancer.
迅速涌现的突破性发现为乳腺癌信号转导景观提供了近乎完整的解析，科学家们已经绘制出与人类基因组编码的蛋白质相关的知识空白图谱。基于数十年研究中获得的见解，似乎很明显，配体通过特定受体传递不同的信息，这些信息被转化为独特的生物学输出。成像、结构生物学、蛋白质组学和基因组编辑方面的进展帮助我们深入了解 JAK-STAT 信号转导，以及该途径的改变如何导致乳腺癌的发展和转移扩散。通过高通量技术获得的数据开始揭示 JAK-STAT 信号转导过程中形成的信号转导复合物。药理学家和分子生物学家正在专注于制定治疗靶向该途径的策略，以克服与乳腺癌相关的耐药性。
