Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, PR China.
Department of Obstetrics & Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, 201620, PR China.
Nanomedicine (Lond). 2019 Sep;14(18):2395-2408. doi: 10.2217/nnm-2018-0398. Epub 2019 Aug 28.
Multidrug resistance is the main reason for the failure of chemotherapy during the treatment of the tumor. To overcome multidrug resistance, this study attempts to develop a novel transdermal drug-delivery system (TDDS) loading cytotoxic drug and chemosensitizer. The polyethylenimine-modified ethosomes (Eth) and sodium cholate-modified ethosomes (Eth) were firstly fabricated, and then a novel TDDS based on the carriers complex of Eth/Eth was prepared by electrostatic interaction and evaluated both and . The Eth/Eth showed the excellent antitumor effect on treating melanoma, using doxorubicin and curcumin as the cytotoxic drug and chemosensitizer, respectively. The as-prepared TDDS composed of Eth/Eth loading multidrug is an effective means for treating melanoma.
多药耐药性是肿瘤治疗中化疗失败的主要原因。为了克服多药耐药性，本研究试图开发一种新型的载细胞毒性药物和化疗增敏剂的透皮给药系统（TDDS）。首先制备了聚乙二胺修饰的醇质体（Eth）和胆酸钠修饰的醇质体（Eth），然后通过静电相互作用制备了基于 Eth/Eth 载体复合物的新型 TDDS，并对其进行了评价。Eth/Eth 对治疗黑色素瘤具有优异的抗肿瘤作用，分别以阿霉素和姜黄素作为细胞毒性药物和化疗增敏剂。由 Eth/Eth 负载多药组成的所制备的 TDDS 是治疗黑色素瘤的有效手段。
