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心力衰竭与认知障碍:临床相关性及治疗考量

Heart Failure and Cognitive Impairment: Clinical Relevance and Therapeutic Considerations.

作者信息

Mene-Afejuku Tuoyo O, Pernia Monica, Ibebuogu Uzoma N, Chaudhari Shobhana, Mushiyev Savi, Visco Ferdinand, Pekler Gerald

机构信息

Department of Medicine, New York Medical College, Metropolitan Hospital Center, New York NY, United States.

Department of Internal Medicine (Cardiology), University of Tennessee Health Sciences Center, Memphis, Tennessee TN, United States.

出版信息

Curr Cardiol Rev. 2019;15(4):291-303. doi: 10.2174/1573403X15666190313112841.

Abstract

Heart failure (HF) is a devastating condition characterized by poor quality of life, numerous complications, high rate of readmission and increased mortality. HF is the most common cause of hospitalization in the United States especially among people over the age of 64 years. The number of people grappling with the ill effects of HF is on the rise as the number of people living to an old age is also on the increase. Several factors have been attributed to these high readmission and mortality rates among which are; poor adherence with therapy, inability to keep up with clinic appointments and even failure to recognize early symptoms of HF deterioration which may be a result of cognitive impairment. Therefore, this review seeks to compile the most recent information about the links between HF and dementia or cognitive impairment. We also assessed the prognostic consequences of cognitive impairment complicating HF, therapeutic strategies among patients with HF and focus on future areas of research that would reduce the prevalence of cognitive impairment, reduce its severity and also ameliorate the effect of cognitive impairment coexisting with HF.

摘要

心力衰竭(HF)是一种严重的疾病,其特征为生活质量差、并发症众多、再入院率高和死亡率增加。HF是美国住院的最常见原因,尤其是在64岁以上的人群中。随着老年人数量的增加,受HF不良影响的人数也在上升。导致这些高再入院率和死亡率的因素有很多,其中包括:治疗依从性差、无法按时就诊,甚至未能识别HF恶化的早期症状,而这可能是认知障碍的结果。因此,本综述旨在汇编有关HF与痴呆或认知障碍之间联系的最新信息。我们还评估了并发HF的认知障碍的预后后果、HF患者的治疗策略,并关注未来的研究领域,这些领域将降低认知障碍的患病率、减轻其严重程度,并改善与HF共存的认知障碍的影响。

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