Center of Clinical Medical Research, The Affiliated Suqian First People's Hospital of Xuzhou Medical University, Suqian, Jiangsu, China.
Institute of Molecular Biology & Translational Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu, China.
Curr Probl Cardiol. 2022 Dec;47(12):101354. doi: 10.1016/j.cpcardiol.2022.101354. Epub 2022 Aug 12.
Cognitive impairment is a frequent condition in patients with heart failure (HF). This meta-analysis aimed to evaluate the prognostic impact of cognitive impairment on all-cause mortality and readmission among HF patients. We systematically searched articles indexing in PubMed and Embase databases until August 5, 2022. Original studies investigating the association of cognitive impairment with mortality and/or readmission for more than 3-month follow-up in patients with HF were selected. Twelve studies including 9556 patients were eligible. The prevalence of cognitive impairment ranged from 13.5% to 63.4% in HF patients. For patients with cognitive impairment vs those without, the pooled adjusted risk ratio (RR) was 1.88 (95% confidence intervals [CI] 1.42-2.48) for all-cause mortality, 1.48 (95% CI 1.19-1.84) for readmission, and 1.53 (95% CI 1.35-1.73) for combined endpoints of all-cause mortality/readmission, respectively. Cognitive impairment is a significant predictor of all-cause mortality/readmission in patients with HF, even after adjustment for the conventional confounding. Evaluation of cognitive function may help to improve risk classification of HF patients.
认知障碍是心力衰竭（HF）患者的常见病症。本荟萃分析旨在评估认知障碍对 HF 患者全因死亡率和再入院的预后影响。我们系统地检索了 PubMed 和 Embase 数据库中的文章，检索时间截至 2022 年 8 月 5 日。选择了研究认知障碍与 HF 患者死亡率和/或超过 3 个月随访时间再入院之间关联的原始研究。符合条件的研究共有 12 项，涉及 9556 例患者。HF 患者中认知障碍的患病率范围为 13.5%至 63.4%。与无认知障碍的患者相比，有认知障碍的患者全因死亡率的合并调整风险比（RR）为 1.88（95%置信区间[CI]1.42-2.48），再入院的 RR 为 1.48（95%CI1.19-1.84），全因死亡率/再入院的合并终点 RR 为 1.53（95%CI1.35-1.73）。认知障碍是 HF 患者全因死亡率/再入院的重要预测因素，即使在调整了常规混杂因素后也是如此。评估认知功能可能有助于改善 HF 患者的风险分层。
