Zhou Yunxiang, Shao Anwen, Xu Weilin, Wu Haijian, Deng Yongchuan
Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Cell Neurosci. 2019 Aug 13;13:301. doi: 10.3389/fncel.2019.00301. eCollection 2019.
Traumatic brain injury (TBI) is an important cause of human mortality and morbidity, which can induce serious neurological damage. At present, clinical treatments for neurological dysfunction after TBI include hyperbaric oxygen, brain stimulation and behavioral therapy, but the therapeutic effect is not satisfactory. Recent studies have found that exogenous stem cells can migrate to damaged brain tissue, then participate in the repair of damaged brain tissue by further differentiation to replace damaged cells, while releasing anti-inflammatory factors and growth factors, thereby significantly improving neurological function. This article will mainly review the effects, deficiencies and related mechanisms of different types of stem cells in TBI.
创伤性脑损伤（TBI）是人类死亡和发病的重要原因，可导致严重的神经损伤。目前，TBI后神经功能障碍的临床治疗方法包括高压氧、脑刺激和行为疗法，但治疗效果并不理想。最近的研究发现，外源性干细胞可以迁移到受损的脑组织，然后通过进一步分化参与受损脑组织的修复，以替代受损细胞，同时释放抗炎因子和生长因子，从而显著改善神经功能。本文将主要综述不同类型干细胞在TBI中的作用、不足及相关机制。
