儿童创伤性脑损伤的干细胞治疗。

Department of Pediatrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.

Int J Mol Sci. 2023 Sep 28;24(19):14706. doi: 10.3390/ijms241914706.

Pediatric traumatic brain injury is a cause of major mortality, and resultant neurological sequelae areassociated with long-term morbidity. Increasing studies have revealed stem cell therapy to be a potential new treatment. However, much work is still required to clarify the mechanism of action of effective stem cell therapy, type of stem cell therapy, optimal timing of therapy initiation, combination of cocurrent medical treatment and patient selection criteria. This paper will focus on stem cell therapy in children with traumatic brain injury.

小儿创伤性脑损伤是导致高死亡率的原因，由此导致的神经后遗症与长期发病率相关。越来越多的研究表明，干细胞治疗是一种有潜力的新疗法。然而，仍需要大量的工作来阐明有效的干细胞治疗的作用机制、干细胞治疗的类型、治疗开始的最佳时机、联合同期的医疗和患者选择标准。本文将重点介绍创伤性脑损伤患儿的干细胞治疗。