Sriyanti Roza, Mose Johanes C, Masrul Masrul, Suharti Netti
Postgraduate Biomedical Science, Faculty of Medicine, Andalas University, Padang, Indonesia.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Dr M. Djamil Central General Hospital, Padang, Indonesia.
Open Access Maced J Med Sci. 2019 Jul 13;7(13):2133-2137. doi: 10.3889/oamjms.2019.601. eCollection 2019 Jul 15.
Preeclampsia can be divided into early (EOPE) and late (LOPE) onset preeclampsia. Preeclampsia is related to the failure of placentation. Accumulation of hypoxia-inducible factors (HIF)-1α is commonly an acute and beneficial respond to hypoxia, while chronically elevated is associated with preeclampsia.
This study aims to evaluate the serum levels of HIF-1α in preeclampsia and normal pregnancy, and to compare the difference between early-onset and late-onset preeclampsia.
A cross-sectional comparative study was conducted among a total of 69 pregnant women at ≥ 20 weeks of gestation, were recruited at obstetrics and gynaecology department at Dr M. Djamil Padang Hospital, network hospitals, health centres. They were divided into three groups early-onset preeclampsia, late-onset preeclampsia, and normal pregnancy. Preeclampsia was diagnosed using International Guidelines. Data were analysed by SPSS 24 program; data are presented as median and range or as mean ± standard deviation. One-way ANOVA test was used to determine the relationship between HIF-1α levels with the onset of preeclampsia.
The results showed that the mean maternal serum HIF-1α levels in early-onset preeclampsia (EOPE), late-onset preeclampsia (LOPE), and normal pregnancy were 1366.96 ± 733.40 pg/ml, 916.87 ± 466.06 pg/ml, and 716.77 ± 541.08 pg/ml. Serum HIF-1α levels were higher in early-onset preeclampsia (EOPE), and late-onset preeclampsia (LOPE) compared to normal pregnancy. Among preeclampsia patients, serum HIF-1α was higher in EOPE than LOPE women. Statistical analysis revealed a significant difference in mean maternal serum HIF-1α between early-onset preeclampsia, late-onset preeclampsia, and normal pregnancy (p < 0.05).
This study concluded that there is a significantly different level of HIF-1α between in early-onset preeclampsia, late-onset preeclampsia and normal pregnancy. Early-onset preeclampsia is the highest levels of serum HIF-1α.
子痫前期可分为早发型（EOPE）和晚发型（LOPE）子痫前期。子痫前期与胎盘形成失败有关。缺氧诱导因子（HIF）-1α的积累通常是对缺氧的一种急性且有益的反应，而长期升高则与子痫前期有关。
本研究旨在评估子痫前期和正常妊娠孕妇血清中HIF-1α的水平，并比较早发型和晚发型子痫前期之间的差异。
在M. 贾米尔博士巴东医院妇产科、网络医院、健康中心招募了总共69名妊娠≥20周的孕妇，进行横断面比较研究。她们被分为三组：早发型子痫前期组、晚发型子痫前期组和正常妊娠组。子痫前期采用国际指南进行诊断。数据通过SPSS 24程序进行分析；数据以中位数和范围或均值±标准差表示。采用单因素方差分析来确定HIF-1α水平与子痫前期发病之间的关系。
结果显示，早发型子痫前期（EOPE）、晚发型子痫前期（LOPE）和正常妊娠孕妇血清HIF-1α的平均水平分别为1366.96±733.40 pg/ml、916.87±466.06 pg/ml和716.77±541.08 pg/ml。与正常妊娠相比，早发型子痫前期（EOPE）和晚发型子痫前期（LOPE）的血清HIF-1α水平更高。在子痫前期患者中，早发型子痫前期患者的血清HIF-1α高于晚发型子痫前期患者。统计分析显示，早发型子痫前期、晚发型子痫前期和正常妊娠孕妇血清HIF-1α的均值存在显著差异（p<0.05）。
本研究得出结论，早发型子痫前期、晚发型子痫前期和正常妊娠孕妇血清HIF-1α水平存在显著差异。早发型子痫前期的血清HIF-1α水平最高。
