Lin Zhuo-Ling, Lin Duo-Ru, Chen Jing-Jing, Li Jing, Li Xiao-Yan, Wang Li-Sha, Liu Zhen-Zhen, Cao Qian-Zhong, Chen Chuan, Zhu Yi, Chen Wei-Rong, Liu Yi-Zhi, Lin Hao-Tian
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.
Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Int J Ophthalmol. 2019 Aug 18;12(8):1323-1329. doi: 10.18240/ijo.2019.08.14. eCollection 2019.
To investigate the behavioral and psychological disorders and the prevalence of parent ratings of attention deficit hyperactivity disorder (ADHD) symptoms among children with bilateral congenital cataracts (CCs).
This cross-sectional study investigated children with bilateral CC aged 3-8y (CC group) using Conners' Parent Rating Scale-48 (CPRS-48) from July to December 2016. The abnormal rates of psychological symptoms in CC children and normal vision (NV) children were compared using the Chi-square test. The scores of CC children were compared with those of NV children and the Chinese urban norm using the independent samples -test and one-sample -test, respectively.
A total of 262 valid questionnaires were collected. The ratio of CC children to NV children was 119:143. The overall rate of psychological symptoms in CC children was 2.28 times higher than that in NV children (46.22% 20.28%, Pearson's =20.062; <0.001). CC children showed higher scores for conduct problems, learning problems, impulsiveness/hyperactivity, anxiety, and hyperactivity index than NV children and the Chinese urban norm, particularly between the ages of 3 and 5y. Furthermore, male children aged between 6 and 8y showed a higher impulsive/hyperactive score than females of the same age (=6.083, <0.001).
Children with bilateral CCs have a higher rate of ADHD symptoms than children with NV. This study provides clinical evidence that screening for psychological symptoms and particularly for ADHD symptoms in children with bilateral CC are recommended for an early diagnosis and timely treatment.
探讨双侧先天性白内障（CC）患儿的行为和心理障碍以及家长对注意力缺陷多动障碍（ADHD）症状的评定患病率。
本横断面研究于2016年7月至12月，使用Conners家长评定量表-48（CPRS-48）对3至8岁的双侧CC患儿（CC组）进行调查。采用卡方检验比较CC患儿和正常视力（NV）患儿心理症状的异常率。分别使用独立样本t检验和单样本t检验将CC患儿的得分与NV患儿以及中国城市常模的得分进行比较。
共收集到262份有效问卷。CC患儿与NV患儿的比例为119:143。CC患儿心理症状的总体发生率比NV患儿高2.28倍（46.22%对20.28%，Pearson卡方值=20.062；P<0.001）。CC患儿在行为问题、学习问题、冲动/多动、焦虑和多动指数方面的得分高于NV患儿和中国城市常模，尤其是在3至5岁之间。此外，6至8岁的男性患儿冲动/多动得分高于同龄女性（t=6.083，P<0.001）。
双侧CC患儿ADHD症状的发生率高于NV患儿。本研究提供了临床证据，建议对双侧CC患儿进行心理症状筛查，尤其是ADHD症状筛查，以便早期诊断和及时治疗。
