Khatoonabadi Ahmad R, Masumi Jafar
Speech Therapy Department, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
Department of Speech Therapy, School of Rehabilitation, Tabriz University of Medical Sciences, Tabriz, Iran.
Med J Islam Repub Iran. 2019 Jun 10;33:53. doi: 10.34171/mjiri.33.53. eCollection 2019.
The present study will be a longitudinal investigation of language abilities in individuals with mild cognitive impairment (MCI). The research question will include whether there will be an evidence for language impairment in individuals with MCI, and if so, what aspects of language will be the most affected and whether language abilities will be significantly changed over a 12-month period. We will diagnose 30 individuals with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controlled participants using Montreal Cognitive Assessment-Basic (MoCA-B), as a cognitive test, and by asking expert opinions and conducting interviews. Participants will be selected from memory clinics and nursing homes in Tehran during 2018-2019. A comprehensive language test (Barnes Language Assessment (BLA)) will be performed to obtain baseline performance in the elderly. These tests will be repeated after 3, 6, and 12 months. Repeated measures analysis of variance (ANOVA) will be used to determine whether there will be a significant change in participants' language abilities over a 12-month period. In the case of deficient language performance, a discriminant function analysis will be used to identify the language task type that will be highly sensitive to change. The present study will provide evidence for the nature of language change and will be done in a-year course on individuals with MCI and AD and on healthy elders. Also, in this study, the relative sensitivity of various language components to MCI will be determined, and the relationship between language performance and performance on (MoCA-B) neuropsychological test will be examined.
本研究将对轻度认知障碍（MCI）患者的语言能力进行纵向调查。研究问题将包括：MCI患者是否存在语言障碍的证据；如果存在，语言的哪些方面受影响最大；以及语言能力在12个月内是否会发生显著变化。我们将使用蒙特利尔认知评估基础版（MoCA-B）作为认知测试，并通过征求专家意见和进行访谈，对30名轻度认知障碍（MCI）患者、阿尔茨海默病（AD）患者和对照参与者进行诊断。参与者将在2018年至2019年期间从德黑兰的记忆诊所和养老院中选取。将进行一项全面的语言测试（巴恩斯语言评估（BLA）），以获取老年人的基线表现。这些测试将在3个月、6个月和12个月后重复进行。重复测量方差分析（ANOVA）将用于确定参与者的语言能力在12个月内是否会有显著变化。如果语言表现不足，将使用判别函数分析来确定对变化高度敏感的语言任务类型。本研究将为语言变化的性质提供证据，并将在为期一年的过程中对MCI和AD患者以及健康老年人进行研究。此外，在本研究中，将确定各种语言成分对MCI的相对敏感性，并考察语言表现与（MoCA-B）神经心理测试表现之间的关系。
