胰岛素样生长因子-1（IGF-1）在肥胖、心血管疾病及癌症中的作用。
The role of IGF-1 in obesity, cardiovascular disease, and cancer.
作者信息
AsghariHanjani Nazanin, Vafa Mohammadreza
机构信息
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Med J Islam Repub Iran. 2019 Jun 17;33:56. doi: 10.34171/mjiri.33.56. eCollection 2019.
Abstract
Insulin-like growth factor1 (IGF1) is a polypeptide that structurally is similar to human pro-insulin, one of the factors that is altered in obesity and many related diseases, hence a large body of research devoted to evaluate it. In this mini-review, we briefly explain the role of IGF1 in different conditions, including obesity, cardiovascular disease, and cancer through the results of review and original articles in both animal and human studies. The short-term metabolic effect of IGF-1 is insulin-like, and its long-term effect is growth factor-like. IGF1 has different roles in the initiation and progression of different diseases, because in some cases, the anti-apoptotic effect, can help cell survival while in others, it may lead to cancer or increment of adipocytes. It is highly recommended to consider the different impacts of IGF1 in health and diseases prevention in future studies and interventions.
摘要
胰岛素样生长因子1（IGF1）是一种多肽，其结构与人类胰岛素原相似，是肥胖及许多相关疾病中发生改变的因素之一，因此有大量研究致力于对其进行评估。在本综述中，我们通过动物和人体研究的综述及原创文章结果，简要阐述IGF1在不同情况下的作用，包括肥胖、心血管疾病和癌症。IGF-1的短期代谢作用类似胰岛素，其长期作用则类似生长因子。IGF1在不同疾病的发生和发展中具有不同作用，因为在某些情况下，其抗凋亡作用可帮助细胞存活，而在其他情况下，它可能导致癌症或脂肪细胞增加。强烈建议在未来的研究和干预中考虑IGF1对健康和疾病预防的不同影响。
相似文献
1
The role of IGF-1 in obesity, cardiovascular disease, and cancer.胰岛素样生长因子-1（IGF-1）在肥胖、心血管疾病及癌症中的作用。
Med J Islam Repub Iran. 2019 Jun 17;33:56. doi: 10.34171/mjiri.33.56. eCollection 2019.
2
Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families.胰岛素样生长因子-1基因型可预测妊娠及激素避孕后的乳房体积，并与循环胰岛素样生长因子-1水平相关：对遗传性乳腺癌家族年轻女性早发性乳腺癌风险的影响。
Int J Gynecol Cancer. 2006;16 Suppl 2:497. doi: 10.1111/j.1525-1438.2006.00678.x.
3
Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1).间歇性高血糖浓度通过改变胰岛素样生长因子（IGF）系统降低神经元前体细胞的存活率：神经保护因子DHCR24（Seladin-1）的作用。
J Endocrinol. 2008 Sep;198(3):523-32. doi: 10.1677/JOE-07-0613. Epub 2008 Jul 8.
4
Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer.胰岛素样生长因子1和IGF结合蛋白3基因多态性与结直肠癌风险
Cancer Detect Prev. 2007;31(5):408-16. doi: 10.1016/j.cdp.2007.10.001. Epub 2007 Nov 26.
5
Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer.重组 PAPP-A 抵抗型胰岛素样生长因子结合蛋白 4（dBP4）抑制乳腺癌小鼠模型中的血管生成和转移。
BMC Cancer. 2018 Oct 22;18(1):1016. doi: 10.1186/s12885-018-4950-0.
6
Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase.与持续的蛋白激酶B磷酸化相关的肿瘤细胞凋亡的预防，相较于增殖刺激和细胞外信号调节激酶，对胰岛素信号调节更为敏感。
Mol Cell Biochem. 2017 Aug;432(1-2):41-54. doi: 10.1007/s11010-017-2996-y. Epub 2017 Mar 18.
7
Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1.肥胖和代谢功能障碍严重影响前列腺细胞功能：胰岛素和胰岛素样生长因子1的作用。
J Cell Mol Med. 2017 Sep;21(9):1893-1904. doi: 10.1111/jcmm.13109. Epub 2017 Feb 28.
8
The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice.胰岛素样生长因子-1在胰高血糖素样肽-2对小鼠肠道的促生长作用中的重要作用。
Gastroenterology. 2006 Aug;131(2):589-605. doi: 10.1053/j.gastro.2006.05.055.
9
Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor.人胰岛素样生长因子1前体通过胰岛素样生长因子1受体诱导乳腺癌细胞增殖。
Cell Oncol (Dordr). 2016 Apr;39(2):149-59. doi: 10.1007/s13402-015-0263-3. Epub 2015 Dec 23.
10
Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain.棕榈酸酯诱导的内质网应激及随后的C/EBPα同源蛋白激活会减弱大脑中瘦素和胰岛素样生长因子1的表达。
Cell Signal. 2016 Nov;28(11):1789-805. doi: 10.1016/j.cellsig.2016.08.012. Epub 2016 Aug 20.
引用本文的文献
1
Effects of IGF1 rs6214 Polymorphism and Milk Consumption on Serum Levels of IGF-1 and GH and Body Composition.胰岛素样生长因子1（IGF1）rs6214基因多态性与牛奶摄入量对血清IGF-1、生长激素（GH）水平及身体成分的影响
Metabolites. 2025 Aug 20;15(8):556. doi: 10.3390/metabo15080556.
2
Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines.年龄相关性及绝经后乳腺癌的进展与治疗管理：促炎细胞因子和CXC趋化因子的意义
Genes Dis. 2025 Mar 19;12(5):101606. doi: 10.1016/j.gendis.2025.101606. eCollection 2025 Sep.
3
Adipose Tissue-Derived Mediators in Multiple Myeloma: Linking Obesity to Bone Disease via Inflammatory Pathways.多发性骨髓瘤中脂肪组织衍生的介质：通过炎症途径将肥胖与骨病联系起来。
Int J Mol Sci. 2025 Jun 11;26(12):5618. doi: 10.3390/ijms26125618.
4
Metabolic Signalling Peptides and Their Relation to Clinical and Demographic Characteristics in Acute and Recovered Females with Anorexia Nervosa.代谢信号肽及其与急性和康复期神经性厌食症女性临床及人口统计学特征的关系
Nutrients. 2025 Apr 14;17(8):1341. doi: 10.3390/nu17081341.
5
Increased Risk of Cancer-An Integral Component of the Cardio-Renal-Metabolic Disease Cluster and Its Management.癌症风险增加——心肾代谢疾病集群的一个组成部分及其管理
Cells. 2025 Apr 9;14(8):564. doi: 10.3390/cells14080564.
6
Effectiveness of low-fat diet on the levels of insulin-like growth factor-1 and insulin-like growth factor binding proteins: a systematic review and meta-analysis of randomized controlled clinical trials.低脂饮食对胰岛素样生长因子-1 及胰岛素样生长因子结合蛋白水平的影响：一项随机对照临床试验的系统评价和荟萃分析。
J Health Popul Nutr. 2024 Nov 29;43(1):201. doi: 10.1186/s41043-024-00698-x.
7
Cardiovascular Effects of Excess Growth Hormone: How Real is the Threat?生长激素过量的心血管影响：威胁究竟有多大？
Rev Cardiovasc Med. 2023 Mar 23;24(4):95. doi: 10.31083/j.rcm2404095. eCollection 2023 Apr.
8
Not Only Metabolic Complications of Childhood Obesity.不仅是儿童肥胖的代谢并发症。
Nutrients. 2024 Feb 15;16(4):539. doi: 10.3390/nu16040539.
9
Indian Almond ( Linn.) Leaf Extract Extends Lifespan by Improving Lipid Metabolism and Antioxidant Activity Dependent on AMPK Signaling Pathway in under High-Glucose-Diet Conditions.印度苦楝叶提取物通过改善高糖饮食条件下依赖AMPK信号通路的脂质代谢和抗氧化活性来延长寿命。
Antioxidants (Basel). 2023 Dec 20;13(1):14. doi: 10.3390/antiox13010014.
10
The Associations of Breastfeeding Status at 6 Months with Anthropometry, Body Composition, and Cardiometabolic Markers at 5 Years in the Ethiopian Infant Anthropometry and Body Composition Birth Cohort.《埃塞俄比亚婴幼儿人体测量和身体成分队列研究：6 月龄母乳喂养状况与 5 岁时人体测量学、身体成分和心血管代谢标志物的关系》。
Nutrients. 2023 Oct 29;15(21):4595. doi: 10.3390/nu15214595.
本文引用的文献
1
Insulin, carbohydrate restriction, metabolic syndrome and cancer.胰岛素、碳水化合物限制、代谢综合征与癌症。
Expert Rev Endocrinol Metab. 2015 Jan;10(1):15-24. doi: 10.1586/17446651.2014.960392. Epub 2014 Sep 22.
2
Dietary Carbohydrates Impair Healthspan and Promote Mortality.饮食中的碳水化合物会损害健康寿命并导致死亡。
Cell Metab. 2017 Oct 3;26(4):585-587. doi: 10.1016/j.cmet.2017.09.011.
3
Disentangling High Fat, Low Carb, and Healthy Aging.解析高脂肪、低碳水化合物与健康老龄化。
Cell Metab. 2017 Sep 5;26(3):458-459. doi: 10.1016/j.cmet.2017.08.020.
4
Diabetes mellitus, insulin resistance and hepatitis C virus infection: A contemporary review.糖尿病、胰岛素抵抗与丙型肝炎病毒感染：当代综述
World J Gastroenterol. 2017 Mar 7;23(9):1697-1711. doi: 10.3748/wjg.v23.i9.1697.
5
Dietary protein, aging and nutritional geometry.饮食蛋白质、衰老与营养几何
Ageing Res Rev. 2017 Oct;39:78-86. doi: 10.1016/j.arr.2017.03.001. Epub 2017 Mar 6.
6
Impact of carbohydrate restriction in the context of obesity on prostate tumor growth in the Hi-Myc transgenic mouse model.在肥胖背景下碳水化合物限制对Hi-Myc转基因小鼠模型中前列腺肿瘤生长的影响。
Prostate Cancer Prostatic Dis. 2017 Jun;20(2):165-171. doi: 10.1038/pcan.2016.73. Epub 2017 Feb 28.
7
The role of dietary carbohydrates in organismal aging.膳食碳水化合物在机体衰老中的作用。
Cell Mol Life Sci. 2017 May;74(10):1793-1803. doi: 10.1007/s00018-016-2432-6. Epub 2016 Dec 10.
8
Preliminary data on the relationship between circulating levels of Sirtuin 4, anthropometric and metabolic parameters in obese subjects according to growth hormone/insulin-like growth factor-1 status.根据生长激素/胰岛素样生长因子-1状态，关于肥胖受试者中沉默调节蛋白4的循环水平、人体测量和代谢参数之间关系的初步数据。
Growth Horm IGF Res. 2015 Feb;25(1):28-33. doi: 10.1016/j.ghir.2014.10.006. Epub 2014 Oct 28.
9
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.炎症作为肥胖、代谢综合征和 2 型糖尿病之间的联系。
Diabetes Res Clin Pract. 2014 Aug;105(2):141-50. doi: 10.1016/j.diabres.2014.04.006. Epub 2014 Apr 13.
10
Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease.肥胖及其代谢并发症：脂肪因子的作用以及肥胖、炎症、胰岛素抵抗、血脂异常与非酒精性脂肪性肝病之间的关系。
Int J Mol Sci. 2014 Apr 11;15(4):6184-223. doi: 10.3390/ijms15046184.
Zotero 插件