碘克沙醇制备过程中一种所谓副产物前体的合成

Haarr Marianne Bore, Lindbäck Emil, Håland Torfinn, Sydnes Magne O

Faculty of Science and Technology, Department of Mathematics and Natural Sciences, University of Stavanger, NO-4036 Stavanger, Norway.

GE Healthcare AS, NO-4521 Lindesnes, Norway.

ACS Omega. 2018 Jul 5;3(7):7344-7349. doi: 10.1021/acsomega.8b00411. eCollection 2018 Jul 31.

, -Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(-(oxiran-2-ylmethyl)acetamido)isophthalamide (), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from 5-acetamido- , -bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (), has been successfully prepared with an overall yield of 25%. Epoxide enabled the confirmation of its presence in the reaction mixture during the preparation of iodixanol when amide was used as the starting material.

1,3 - 双(2,3 - 二羟基丙基)-2,4,6 - 三碘 - 5 - [N - (环氧乙烷 - 2 - 基甲基)乙酰胺基]间苯二甲酰胺（），据称是在由5 - 乙酰胺基 - 1,3 - 双(2,3 - 二羟基丙基)-2,4,6 - 三碘间苯二甲酰胺（）合成X射线造影剂碘克沙醇时形成的几种次要副产物的前体，已成功制备，总产率为25%。环氧化物能够在以酰胺为起始原料制备碘克沙醇的过程中确认其在反应混合物中的存在。