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用于淬灭和纯化四丁基氟化铵介导的脱硅反应的混合树脂床。

A mixed resin bed for the quenching and purification of tetrabutylammonium fluoride mediated desilylating reactions.

作者信息

Parlow J J, Vazquez M L, Flynn D L

机构信息

Parallel Medicinal and Combinatorial Chemistry, Searle Discovery Research-U2D Monsanto Company, St. Louis, MO 63167, USA.

出版信息

Bioorg Med Chem Lett. 1998 Sep 8;8(17):2391-4. doi: 10.1016/s0960-894x(98)00432-6.

DOI:10.1016/s0960-894x(98)00432-6
PMID:9873547
Abstract

A polymer-bound calcium sulfonate resin is prepared and used to sequester tetrabutylammonium fluoride. The simultaneous use of the calcium sulfonate resin with a sulfonic acid resin is used for the quenching and purification of desilylating reactions involving tetrabutylammonium fluoride as the reagent. Employment of this resin workup technique eliminates the need for a liquid-phase extractive protocol allowing the procedure to be easily automated.

摘要

制备了一种聚合物负载的磺酸钙树脂，并用于螯合四丁基氟化铵。磺酸钙树脂与磺酸树脂同时使用，用于淬灭和纯化以四丁基氟化铵为试剂的去硅基化反应。采用这种树脂后处理技术无需液相萃取方案，使该过程易于自动化。

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