有机催化对映选择性曼尼希反应：直接合成手性β-氨基酯。
Organocatalytic Enantioselective Mannich Reaction: Direct Access to Chiral β-Amino Esters.
作者信息
Ravi Kumar G, Ramesh Boora, Yarlagadda Suresh, Sridhar Balasubramanian, Reddy B V Subba
机构信息
Fluoro & Agrochemicals and Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
出版信息
ACS Omega. 2019 Jan 29;4(1):2168-2177. doi: 10.1021/acsomega.8b02132. eCollection 2019 Jan 31.
An asymmetric Mannich reaction has been developed to generate chiral β-amino esters in good yields with excellent enantiomeric excesses (ee, up to 99%) using a chiral bifunctional thiourea catalyst derived from (,)-cyclohexyldiamine. This is the first report on the addition of 3-indolinone-2-carboxylates to -Boc-benzaldimines generated in situ from α-amidosulfones, which proceeds under mild conditions.
已经开发出一种不对称曼尼希反应，使用由（，）-环己二胺衍生的手性双功能硫脲催化剂，以良好的产率和优异的对映体过量（ee，高达99%）生成手性β-氨基酯。这是关于将3-吲哚酮-2-羧酸酯加成到由α-氨基砜原位生成的-Boc-苯甲醛亚胺的首次报道，该反应在温和条件下进行。
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