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用于生物医学应用的杂化聚乙二醇化单吡啶甲酸环金属配体的设计与合成

Design and Synthesis of Hybrid PEGylated Metal Monopicolinate Cyclam Ligands for Biomedical Applications.

作者信息

Aouidat Fatima, Halime Zakaria, Moretta Rosalba, Rea Ilaria, Filosa Stefania, Donato Stella, Tatè Rosarita, de Stefano Luca, Tripier Raphaël, Spadavecchia Jolanda

机构信息

CNRS, UMR 7244, CSPBAT, Laboratoire de Chimie, Structures et Propriétés de Biomateriaux et d'Agents Therapeutiques Université Paris 13, 1 rue Chablis 93000, Sorbonne Paris Cité, 93000 Bobigny, France.

Universitè de Brest, UMR-CNRS 6521/IBSAM, UFR Sciences et Techniques, 6 Avenue Victor le Gorgeu, C.S. 93837, 29238 Brest, France.

出版信息

ACS Omega. 2019 Feb 1;4(2):2500-2509. doi: 10.1021/acsomega.8b03266. eCollection 2019 Feb 28.

DOI:10.1021/acsomega.8b03266
PMID:31459488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6648416/
Abstract

In this study, we report, for the first time, the synthesis of two original nanosystems, based on gold Au(III) and copper Cu(II): simple gold-copper nanoparticles (CuAuNPs) and enriched monopicolinate cyclam (L1)-Cu(II)-Au(III)-complex (L1@CuAuNPs). The two nanomaterials differ substantially by the chelation or not of the Cu(II) ions during the NPs synthesis process. The two hybrid nanoparticles (CuAuNPs; L1@CuAuNPs) were deeply studied from the chemical and physical point of view, using many different analytical techniques such as Raman and UV-vis spectroscopy, electron transmission microscopy, and dynamic light scattering. Both nanosystems show morphological and good chemical stability at pH 4 values and in physiological conditions during 98 h. Undifferentiated and neural differentiated murine embryonic stem cells were used as a model system for in vitro experiments to reveal the effects of NPs on these cells. The comparative study between CuAuNPs and L1@CuAuNPs highlights that copper chelated in its +2 oxidation state in the NPs is more functional for biological application.

摘要

在本研究中，我们首次报道了基于金Au(III)和铜Cu(II)合成的两种新型纳米系统：简单的金铜纳米颗粒（CuAuNPs）和富集单吡啶甲酸环胺（L1）的Cu(II)-Au(III)络合物（L1@CuAuNPs）。这两种纳米材料在纳米颗粒合成过程中因是否螯合Cu(II)离子而有很大差异。从化学和物理角度对这两种杂化纳米颗粒（CuAuNPs；L1@CuAuNPs）进行了深入研究，使用了许多不同的分析技术，如拉曼光谱和紫外可见光谱、电子透射显微镜以及动态光散射。在pH值为4以及生理条件下98小时内，这两种纳米系统均表现出形态和良好的化学稳定性。未分化和神经分化的小鼠胚胎干细胞被用作体外实验的模型系统，以揭示纳米颗粒对这些细胞的影响。CuAuNPs和L1@CuAuNPs之间的比较研究表明，纳米颗粒中以+2氧化态螯合的铜在生物应用中更具功能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/5b805440e9ea/ao-2018-03266h_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/66c928ebe4d2/ao-2018-03266h_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/3453a789151d/ao-2018-03266h_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/36ba19adc775/ao-2018-03266h_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/d8b3d18e367d/ao-2018-03266h_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/2fd9fd98cbca/ao-2018-03266h_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/197621dbe621/ao-2018-03266h_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/31c8b64414ab/ao-2018-03266h_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/effd0cf9cbaf/ao-2018-03266h_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/5b805440e9ea/ao-2018-03266h_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/66c928ebe4d2/ao-2018-03266h_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/3453a789151d/ao-2018-03266h_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/36ba19adc775/ao-2018-03266h_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/d8b3d18e367d/ao-2018-03266h_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/2fd9fd98cbca/ao-2018-03266h_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/197621dbe621/ao-2018-03266h_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/31c8b64414ab/ao-2018-03266h_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/effd0cf9cbaf/ao-2018-03266h_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753d/6648416/5b805440e9ea/ao-2018-03266h_0009.jpg

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