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硫醇-聚（苯乙烯磺酸钠）（聚NaSS-SH）金配合物：从化学设计到杂化金纳米粒子的一步合成及其与人类蛋白质的相互作用

Thiol-Poly(Sodium Styrene Sulfonate) (PolyNaSS-SH) Gold Complexes: From a Chemical Design to a One-Step Synthesis of Hybrid Gold Nanoparticles and Their Interaction with Human Proteins.

作者信息

Falentin-Daudré Céline, Aitouakli Mounia, Baumann Jean Sébastien, Bouchemal Nadia, Humblot Vincent, Migonney Véronique, Spadavecchia Jolanda

机构信息

CNRS, UMR 7244, NBD-LBPS-CSPBAT, Laboratoire de Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques Université Paris 13, Sorbonne Paris Cité, 93000 Bobigny, France.

FEMTO-ST Institute, UMR CNRS 6174, Université Bourgogne Franche-Comté, 15B avenue des Montboucons, 25030 Besançon Cedex, France.

出版信息

ACS Omega. 2020 Apr 2;5(14):8137-8145. doi: 10.1021/acsomega.0c00376. eCollection 2020 Apr 14.

DOI:10.1021/acsomega.0c00376
PMID:32309723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7161026/
Abstract

This study highlights recent advances in the synthesis of nanoconjugates based on gold (Au(III)) complex with a bioactive polymer bearing sulfonate groups called thiol-poly(sodium styrene sulfonate) (PolyNaSS-SH) with various molecular weights (5, 10, and 35 kDa). The three nanomaterials differ substantially in shape and structure. In particular, for PolyNaSS-SH of 35 kDa, we obtained a characteristic core-shell flower shape after chelation of the Au(III) ions and successively reduction with sodium borohydride (NaBH). The mechanism of formation of the hybrid nanoparticles (PolyNaSS-SH@AuNPs (35 kDa) and their interactions between plasmatic proteins (human serum albumin (HSA), collagen I (Col 1), and fibronectin (Fn)) were deeply studied from a chemical and physical point of view by using several analytical techniques such as Raman spectroscopy, UV-visible, transmission electron microscopy (TEM), H NMR, and X-ray photoelectron spectroscopy (XPS).

摘要

本研究重点介绍了基于金（Au(III)）配合物与一种带有磺酸基团的生物活性聚合物（称为硫醇-聚（苯乙烯磺酸钠）（PolyNaSS-SH））合成纳米共轭物的最新进展，该聚合物具有不同的分子量（5、10和35 kDa）。这三种纳米材料在形状和结构上有很大差异。特别是对于35 kDa的PolyNaSS-SH，在Au(III)离子螯合并随后用硼氢化钠（NaBH）还原后，我们得到了一种特征性的核壳花状结构。通过使用拉曼光谱、紫外可见光谱、透射电子显微镜（TEM）、核磁共振氢谱（H NMR）和X射线光电子能谱（XPS）等多种分析技术，从化学和物理角度深入研究了杂化纳米粒子（PolyNaSS-SH@AuNPs（35 kDa））的形成机制及其与血浆蛋白（人血清白蛋白（HSA）、胶原蛋白I（Col 1）和纤连蛋白（Fn））之间的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/f45c93c1f05b/ao0c00376_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/d1cb0ade4f3f/ao0c00376_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/db043397492a/ao0c00376_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/464a04e14a03/ao0c00376_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/f4840a95cf4c/ao0c00376_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/2d893e7817bb/ao0c00376_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/7a67dc07566d/ao0c00376_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/f45c93c1f05b/ao0c00376_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/d1cb0ade4f3f/ao0c00376_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/db043397492a/ao0c00376_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/464a04e14a03/ao0c00376_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/f4840a95cf4c/ao0c00376_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/2d893e7817bb/ao0c00376_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/7a67dc07566d/ao0c00376_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b58/7161026/f45c93c1f05b/ao0c00376_0004.jpg

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