Zi Quan-Xing, Yan Sheng-Jiao, Yang Chang-Long, Li Kun, Lin Jun
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.
ACS Omega. 2019 Feb 7;4(2):2863-2873. doi: 10.1021/acsomega.8b03284. eCollection 2019 Feb 28.
A novel approach has been developed for the synthesis of three kinds of highly functionalized 2-aminopyridine derivatives (APDs) through a three-component reaction of 1,1-enediamines (EDAMs) , ,-dimethylformamide dimethyl acetal (DMF-DMA) , and 1,3-dicarbonyl compounds - via a base-promoted cascade reaction, producing the desired products in good to excellent yields. This method represents a route to obtain a novel class of APDs in a concise, rapid, and practical manner. This approach is particularly attractive because of the following features: low cost, mild temperature, atom economy, high yields, and potential biological activity of the product.
通过1,1-乙二胺（EDAMs）、N,N-二甲基甲酰胺二甲基缩醛（DMF-DMA）和1,3-二羰基化合物的三组分反应，经由碱促进的级联反应，开发了一种合成三种高度官能化的2-氨基吡啶衍生物（APDs）的新方法，以良好至优异的产率得到所需产物。该方法代表了一种以简洁、快速和实用的方式获得一类新型APDs的途径。这种方法特别具有吸引力，原因如下：成本低、温度温和、原子经济性、产率高以及产物具有潜在的生物活性。
