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线粒体靶向新型蓝光发射荧光分子探针

Mitochondria-Targeted New Blue Light-Emitting Fluorescent Molecular Probe.

作者信息

Mohapatra Saswat, Das Gaurav, Kar Chirantan, Nitani Masashi, Ie Yutaka, Aso Yoshio, Ghosh Surajit

机构信息

Organic and Medicinal Chemistry Division, Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, West Bengal, India.

Academy of Scientific and Innovative Research (AcSIR), Chennai 201002, India.

出版信息

ACS Omega. 2019 May 29;4(5):9361-9366. doi: 10.1021/acsomega.8b03331. eCollection 2019 May 31.

DOI:10.1021/acsomega.8b03331
PMID:31460025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6649077/
Abstract

Discovery of a nontoxic fluorescent molecular probe to "light up" specific cellular organelles is extremely essential to understand dynamics of intracellular components. Here, we report a new nontoxic mitochondria-targeted linear bithiazole compound, containing trifluoroacetyl terminal groups, which emits intense blue fluorescence and stained mitochondria of various cells. Interestingly, the power of fluorescence is completely off when the bithiazole unit is stapled by a carbonyl bridge.

摘要

发现一种无毒的荧光分子探针来“点亮”特定的细胞器对于理解细胞内组分的动态变化极其重要。在此，我们报道了一种新的含有三氟乙酰端基的无毒线粒体靶向线性双噻唑化合物，它能发出强烈的蓝色荧光并对各种细胞的线粒体进行染色。有趣的是，当双噻唑单元通过羰基桥连接时，荧光完全熄灭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/c11e8752eef4/ao-2018-03331e_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/0fe952e8a7b3/ao-2018-03331e_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/968765bd1860/ao-2018-03331e_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/119dfb6f4bd1/ao-2018-03331e_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/f74e5aee20fc/ao-2018-03331e_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/4a4892464857/ao-2018-03331e_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/c11e8752eef4/ao-2018-03331e_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/0fe952e8a7b3/ao-2018-03331e_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/968765bd1860/ao-2018-03331e_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/119dfb6f4bd1/ao-2018-03331e_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/f74e5aee20fc/ao-2018-03331e_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/4a4892464857/ao-2018-03331e_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee99/6649077/c11e8752eef4/ao-2018-03331e_0006.jpg

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