Kadian S K, Monga D P, Goel M C
Department of Veterinary Microbiology, Haryana Agricultural University, Hisar, India.
Mycopathologia. 1988 Oct;104(1):33-6. doi: 10.1007/BF00437921.
Efforts were made to see the effect of feeding aflatoxin B1 at 0.3 ppm level on various aspects of the immune system in chickens. The birds were fed aflatoxin B1 (AFB1) mixed ration from 0 to 6 weeks of age and thereafter normal feed was given up to 12 weeks of age. The delayed type hypersensitivity reaction of these birds was assessed by contact sensitivity to Dinitrofluorobenzene. The dietary AFB1 significantly suppressed the cell mediated immune response at all the three periods tested (30, 45 and 60 days of age). The toxin showed residual effect on immunity as the suppression of cell mediated immunity was maximum three days after the withdrawal of toxin from the feed. The effect of AFB1 on the phagocytic status of reticulo endothelial system (RES) was assessed by colloidal carbon clearance test at various intervals. The residual effect of toxin was observed on RES too as phagocytic index of AFB1 fed birds was significantly lowered up to 45 days of age.
研究人员致力于观察以0.3 ppm水平饲喂黄曲霉毒素B1对鸡免疫系统各个方面的影响。这些鸡从0至6周龄期间被饲喂添加了黄曲霉毒素B1（AFB1）的混合日粮，之后直至12周龄都给予正常饲料。通过对二硝基氟苯的接触敏感性来评估这些鸡的迟发型超敏反应。在所有测试的三个时期（30日龄、45日龄和60日龄），日粮中的AFB1均显著抑制了细胞介导的免疫反应。毒素对免疫力显示出残留效应，因为从饲料中撤出毒素三天后，细胞介导免疫的抑制作用达到最大。通过在不同时间间隔进行的胶体碳清除试验，评估AFB1对网状内皮系统（RES）吞噬状态的影响。毒素对RES也观察到残留效应，因为饲喂AFB1的鸡的吞噬指数在45日龄前显著降低。
