Spooner R L, Innes E A, Glass E J, Millar P, Brown C G
Institute of Animal Physiology, Edinburgh, UK.
Parasite Immunol. 1988 Nov;10(6):619-29. doi: 10.1111/j.1365-3024.1988.tb00249.x.
Bovine mononuclear cell lines infected with the protozoan parasites Theileria annulata and T. parva have been studied with a panel of monoclonal antibodies reacting with bovine lymphocyte subpopulation markers. All infected lines are MHC class II positive, though the amount of class II antigen expressed varied between lines, and within individual lines there was variation in the proportion of positive cells from 100% with many, to less than 10%. All lines were negative for a macrophage/monocyte marker and for surface IgM. The T. parva lines tested were all positive for BoT4 or BoT8 or both, whereas T. annulata lines were uniformly negative for both of these markers. These results suggest that the two parasites preferentially infect different lymphocyte subpopulations.
已使用一组与牛淋巴细胞亚群标志物反应的单克隆抗体，对感染了原虫寄生虫环形泰勒虫和小泰勒虫的牛单核细胞系进行了研究。所有感染的细胞系均为MHC II类阳性，尽管各细胞系之间表达的II类抗原量有所不同，并且在单个细胞系内，阳性细胞的比例也存在差异，从许多细胞系中的100%到不到10%不等。所有细胞系对巨噬细胞/单核细胞标志物和表面IgM均呈阴性。所测试的小泰勒虫细胞系对BoT4或BoT8或两者均呈阳性，而环形泰勒虫细胞系对这两种标志物均呈一致阴性。这些结果表明，这两种寄生虫优先感染不同的淋巴细胞亚群。
