Changhai Hospital, The Second Military Medical University , Yangpu Qu , China.
Dental Medicine MDT Center, The First Hospital of Shanxi Medical University , Taiyuan , China.
J Biomater Sci Polym Ed. 2019 Dec;30(18):1709-1724. doi: 10.1080/09205063.2019.1659711. Epub 2019 Aug 29.
Poly(ether-ether-ketone) (PEEK) has attracted more and more attention due to its chemical resistance, biocompatibility and other properties. Furthermore, carbon fibers-PEEK composite (CF-PEEK) has been considered as a novel implant because of its high mechanical strength and elastic modulus that matching with human bones. However, the length of CF has a great influence on mechanical strength and elastic modulus of the randomly distributed chopped CF-PEEK composites. In this work, CF-PEEK composites with more than 10 times length difference of fibers (length of short CF: 150-200 μm and length of long CF: 2-3 mm) were studied. As the results shown, the mechanical strength (including tensile strength, bending strength and compressive strength) of long CF-PEEK composites were more than two times of that of short CF-PEEK composites. Meanwhile, tensile modulus and bending modulus of the two kinds of composites matched well with the modulus of human cortical bone. In addition, according to the results of cytotoxicity test and hemocompatibility assessment, it indicated that the two kinds of CF-PEEK composites showed mild toxicity and no hemolytic reaction. And the histopathological section of systemic toxicity test showed that the CF-PEEK composites had no obvious acute toxicity to organisms.
聚醚醚酮（PEEK）由于其耐化学性、生物相容性等特性而受到越来越多的关注。此外，碳纤维增强聚醚醚酮复合材料（CF-PEEK）因其高机械强度和弹性模量与人体骨骼相匹配而被认为是一种新型植入物。然而，碳纤维的长度对随机分布的短切碳纤维增强聚醚醚酮复合材料的机械强度和弹性模量有很大的影响。在这项工作中，研究了纤维长度差异超过 10 倍的 CF-PEEK 复合材料（短碳纤维长度：150-200μm，长碳纤维长度：2-3mm）。结果表明，长碳纤维增强聚醚醚酮复合材料的机械强度（包括拉伸强度、弯曲强度和压缩强度）是短碳纤维增强聚醚醚酮复合材料的两倍以上。同时，两种复合材料的拉伸模量和弯曲模量与人类皮质骨的模量匹配良好。此外，根据细胞毒性试验和血液相容性评估的结果，表明两种 CF-PEEK 复合材料表现出轻微的毒性，没有溶血反应。系统毒性试验的组织病理学切片表明，CF-PEEK 复合材料对生物体没有明显的急性毒性。
