Department of Dermatology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
Dermatol Surg. 2010 Apr;36(4):490-5. doi: 10.1111/j.1524-4725.2010.01481.x. Epub 2010 Feb 19.
Chemical peels are becoming more popular as a treatment modality for melasma.
To compare the therapeutic effects of glycolic acid (GA) peels and amino fruit acid (AFA) peels in patients with melasma.
In this single-blind, randomized right-left comparison study, patients received 12 serial peels on the two halves of the face at 2-week intervals for 6 months. Clinical evaluation based on the modified Melasma Area and Severity Index (MASI) scores was performed at baseline and at 3 and 6 months.
The modified MASI scores at 3 and 6 months in both application areas decreased significantly from baseline (p<.05). When the two applications were compared with each other, there was no statistically significant difference between GA and AFA in terms of regression of melasma (p>.05). During the application, it was observed that AFA peels caused fewer problems than GA peels did.
Based on the results of this study, GA and AFA peels for melasma therapy were efficacious, but the AFA peel was found to be less irritating and was better tolerated.
化学焕肤作为一种治疗黄褐斑的方法越来越受欢迎。
比较甘醇酸（GA）焕肤和氨基酸果酸（AFA）焕肤治疗黄褐斑的疗效。
这是一项单盲、随机左右对比研究，患者在 6 个月内每 2 周接受 12 次面部双侧化学焕肤治疗。在基线、3 个月和 6 个月时，根据改良黄褐斑面积和严重程度指数（MASI）评分进行临床评估。
治疗后 3 个月和 6 个月，两个治疗区域的改良 MASI 评分均较基线显著下降（p<.05）。两种方法相比，GA 和 AFA 在黄褐斑消退方面无统计学差异（p>.05）。在应用过程中，AFA 焕肤比 GA 焕肤引起的问题更少。
本研究结果表明，GA 和 AFA 焕肤治疗黄褐斑均有效，但 AFA 焕肤的刺激性较小，患者耐受性更好。
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