Department of Anesthesiology, Faculty of Medicine, Balcalı Hospital, Cukurova University, Adana, Turkey.
Ministry of Health, Provincial Health Directorate, Adana, Turkey.
Bosn J Basic Med Sci. 2020 Feb 5;20(1):117-124. doi: 10.17305/bjbms.2019.4379.
The analgesic benefit of melatonin and vitamin C as primary or adjuvant agents has been reported in various studies; however, their analgesic effects in the treatment of postoperative pain remain unclear. Thus, we aimed to evaluate the effect of single preoperative dose of oral melatonin or vitamin C administration on postoperative analgesia. In this study, we recruited 165 adult patients undergoing elective major abdominal surgery under general anesthesia. Patients were randomly divided into three equal (n = 55) groups. One hour before surgery, patients received orally melatonin (6 mg) in group M, vitamin C (2 g) in group C, or a placebo tablet in group P. Pain, sedation, patient satisfaction, total morphine consumption from a patient-controlled analgesia device, supplemental analgesic requirement, and the incidence of nausea and vomiting were recorded throughout 24 h after surgery. The mean pain score and total morphine consumption were found significantly lower in both M and C groups compared with group P (p < 0.001). There were no significant differences between group M and C with respect to pain scores (p = 0.117) and total morphine consumption (p = 0.090). Patients requested less supplemental analgesic and experienced less nausea and vomiting in groups M and C compared with group P. In conclusion, preoperative oral administration of 6 mg melatonin or 2 g vitamin C led to a reduction in pain scores, total morphine consumption, supplemental analgesic requirement, and the incidence of nausea and vomiting compared with placebo.
在各种研究中已经报道了褪黑素和维生素 C 作为主要或辅助药物的镇痛益处；然而，它们在治疗术后疼痛中的镇痛效果仍不清楚。因此，我们旨在评估术前单次口服褪黑素或维生素 C 给药对术后镇痛的影响。在这项研究中，我们招募了 165 名接受全身麻醉下择期大腹部手术的成年患者。患者被随机分为三组（n = 55）。手术前 1 小时，患者在 M 组口服褪黑素（6 毫克），C 组口服维生素 C（2 克），P 组口服安慰剂片。记录术后 24 小时内的疼痛、镇静、患者满意度、患者自控镇痛装置的总吗啡消耗量、补充镇痛需求以及恶心和呕吐的发生率。与 P 组相比，M 组和 C 组的平均疼痛评分和总吗啡消耗量均显著降低（p < 0.001）。M 组和 C 组之间的疼痛评分（p = 0.117）和总吗啡消耗量（p = 0.090）无显著差异。与 P 组相比，M 组和 C 组的患者要求较少的补充镇痛，且恶心和呕吐的发生率较低。总之，与安慰剂相比，术前口服 6 毫克褪黑素或 2 克维生素 C 可降低疼痛评分、总吗啡消耗量、补充镇痛需求和恶心呕吐的发生率。
