Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital , Central South University , Changsha , Hunan 410083 , China.
Engineering and Technology Research Center for Xenotransplantation of Hunan Province , Changsha , Hunan 410000 , China.
J Am Chem Soc. 2019 Sep 18;141(37):14687-14698. doi: 10.1021/jacs.9b06086. Epub 2019 Sep 6.
Phototheranostics refers to advanced photonics-mediated theranostic methods for cancer and includes imaging-guided photothermal/chemotherapy, photothermal/photodynamic therapy, and photodynamic/chemotherapy, which are expected to provide a paradigm of modern precision medicine. In this regard, various phototheranostic drug delivery systems with excellent photonic performance, controlled drug delivery/release, and precise photoimaging guidance have been developed. In this study, we reported a special "in situ framework growth" method to synthesize novel phototheranostic hollow mesoporous nanoparticles by ingenious hybridization of perylene diimide (PDI) within the framework of small-sized hollow mesoporous organosilica (HMO). The marriage of PDI and HMO endowed the phototheranostic silica nanoparticles (HMPDINs) with largely amplified fluorescence and photoacoustic signals, which can be used for enhanced fluorescence and photoacoustic imaging. The organosilica shell can be chemically chelated with isotope Cu for positron emission tomography imaging. Moreover, in situ polymer growth was introduced in the hollow structure of the HMPDINs to produce thermosensitive polymer (TP) in the cavity of HMPDINs to increase the loading capacity and prevent unexpected leakage of the hydrophobic drug SN38. Furthermore, the framework-hybridized PDI generated heat under near-infrared laser irradiation to trigger the deformation of TP for controlled drug release in the tumor region. The fabricated hybrid nanomedicine with organic-inorganic characteristic not only increases the cancer theranostic efficacy but also offers an attractive solution for designing powerful theranostic platforms.
光热治疗是指利用先进的光子学介导的癌症治疗方法，包括成像引导的光热/化学疗法、光热/光动力疗法和光动力/化学疗法，有望为现代精准医学提供一种范例。在这方面，已经开发出了各种具有优异光子性能、控制药物释放/释放和精确光成像引导的光热治疗药物输送系统。在这项研究中，我们报道了一种特殊的“原位框架生长”方法，通过巧妙地将苝二酰亚胺（PDI）嵌入到小尺寸的中空介孔有机硅（HMO）的框架内，合成了新型的光热治疗中空介孔纳米粒子。PDI 和 HMO 的结合赋予了光热治疗硅纳米粒子（HMPDINs）大大放大的荧光和光声信号，可用于增强荧光和光声成像。有机硅壳可以用同位素 Cu 进行化学螯合，用于正电子发射断层扫描成像。此外，在 HMPDINs 的中空结构中引入了原位聚合生长，以在 HMPDINs 的空腔内产生温敏聚合物（TP），从而增加载药量并防止疏水性药物 SN38 的意外泄漏。此外，框架杂交的 PDI 在近红外激光照射下产生热量，触发 TP 的变形，以在肿瘤区域实现控制药物释放。这种具有有机-无机特性的杂化纳米医学不仅提高了癌症治疗效果，而且为设计强大的治疗平台提供了一种有吸引力的解决方案。
