Kamal Abdellatif Mona, Abdelmaguid Mohamed Elzankalony Yasser, Abdelmonsef Abdelhamid Ebeid Ahmed, Mohamed Ebeid Weam
Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Ophthalmol. 2019 Jul 31;2019:1698967. doi: 10.1155/2019/1698967. eCollection 2019.
To identify and correlate age-related changes in outer retinal layers' thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes.
Observational cross-sectional study.
We studied 125 healthy Egyptians between 20 and 79 years old. Patients were divided into 3 groups: group 1 (20-40 years), group 2 (40-60 years), and group 3 (>60 years). All patients had full ophthalmic examination. SD-OCT was done to measure the 9 ETDRS macular grid sectors of retinal pigment epithelium and photoreceptor outer segment (RPE-OS), outer nuclear layer and photoreceptor inner segment (ONL-IS), and choroidal thickness (CT) (by enhanced depth imaging).
RPE-OS was significantly thinner in group 3 than in the other 2 groups (central: < 0.001). Moreover, the 3 groups were significantly different from each other regarding the CT (central: < 0.001); significant thinning was noticed in the choroid with age. The 3 groups did not show significant difference concerning the ONL-IS thickness. RPE-OS and CT showed statistically significant negative correlation with age (central RPE-OS: = -0 C.345, < 0.001, and central CT: = -0.725, < 0.001) while ONL-IS showed statistically nonsignificant correlation with age (central ONL-IS: = -0.08, =0.376). Multiple regression analysis revealed that the most important determinant of central 1 mm RPE-OS thickness in this study was age ( = -0.087, =0.010) rather than choroidal thinning ( = 0.001, =0.879).
RPE-OS layer thickness shows significant thinning with increasing age, and with decrease in CT, however, age is the most determinant factor of this thinning.
使用频域光学相干断层扫描（SD-OCT）识别正常眼睛视网膜外层厚度和脉络膜厚度（CT）与年龄相关的变化并建立关联，同时研究影响这些变化的因素。
观察性横断面研究。
我们研究了125名年龄在20至79岁之间的健康埃及人。患者被分为3组：第1组（20 - 40岁），第2组（40 - 60岁）和第3组（>60岁）。所有患者均接受了全面的眼科检查。通过SD-OCT测量视网膜色素上皮和光感受器外段（RPE-OS）、外核层和光感受器内段（ONL-IS）的9个ETDRS黄斑网格区域以及脉络膜厚度（CT）（通过增强深度成像）。
第3组的RPE-OS明显比其他两组薄（中央：<0.001）。此外，三组在CT方面也存在显著差异（中央：<0.001）；随着年龄增长，脉络膜明显变薄。三组在ONL-IS厚度方面未显示出显著差异。RPE-OS和CT与年龄呈统计学显著负相关（中央RPE-OS：=-0.345，<0.001，中央CT：=-0.725，<0.001），而ONL-IS与年龄的相关性无统计学意义（中央ONL-IS：=-0.08，=0.376）。多元回归分析显示，本研究中中央1mm RPE-OS厚度的最重要决定因素是年龄（=-0.087，=0.010），而非脉络膜变薄（=0.001，=0.879）。
RPE-OS层厚度随着年龄增长显著变薄，且随着CT降低而变薄，然而，年龄是这种变薄的最主要决定因素。
