Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.
Healthcare Workers Service, ASUR Area 2, Loreto Hospital, Loreto, Italy.
Biomed Res Int. 2019 Jul 31;2019:7582734. doi: 10.1155/2019/7582734. eCollection 2019.
The gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of in healthy volunteers and its expression levels in rotational shift and daytime workers.
expression levels were evaluated in peripheral blood lymphocytes from 15 healthy volunteers at 4-hour intervals for 24 h. Metabolic parameters and expression were measured in workers engaged in shift and daytime work.
In the group of volunteers expression showed diurnal variation, with a peak at 8:00 AM. expression was higher in shift workers than in daytime workers. Multivariate analysis confirmed the role of shift work as an independent factor affecting expression. Notably, its level correlated directly with body mass index and inversely with total energy expenditure.
Measuring expression levels in human peripheral blood lymphocytes can improve investigations on the relationship between changes in circadian rhythm and metabolic disorders. Shift workers show higher levels than daytime workers.
该基因将营养吸收和代谢与生物钟联系起来。轮班工作者超重、肥胖和代谢综合征的风险更高。本研究调查了健康志愿者中 的昼夜变化及其在轮班和白班工作者中的表达水平。
15 名健康志愿者每隔 4 小时采集外周血淋巴细胞，持续 24 小时，评估 表达水平。测量从事轮班和白班工作的工人的代谢参数和 表达。
在志愿者组中， 表达表现出昼夜变化，上午 8 时达到峰值。轮班工人的 表达高于白班工人。多变量分析证实轮班工作是影响 表达的独立因素。值得注意的是，其水平与体重指数直接相关，与总能量消耗成反比。
测量人外周血淋巴细胞中的 表达水平可以提高对昼夜节律变化与代谢紊乱关系的研究。轮班工作者的 水平高于白班工作者。
