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1 型糖尿病中 OX40 和 OX40L 共刺激分子可溶性形式增强和膜型减少。

Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D).

机构信息

Jiangsu Institute of Clinical Immunology, First Affiliated Hospital of Soochow University, Suzhou, China.

Institute of Blood and Marrow Transplantation, First Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

J Immunol Res. 2019 Aug 1;2019:1780567. doi: 10.1155/2019/1780567. eCollection 2019.

DOI:10.1155/2019/1780567
PMID:31467932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6701347/
Abstract

This study analyzed the expression of membrane OX40 and OX40L (mOX40 and mOX40L) and levels of soluble OX40 and OX40L (sOX40 and sOX40L) in T1D patients to determine their clinical significance. Peripheral blood (PB) was collected from patients with T1D and healthy control participants. Expression of mOX40 and mOX40L on immune cells was detected by flow cytometry. Levels of sOX40 and sOX40L in sera were measured by ELISA. We demonstrated for the first time enhanced sOX40 and sOX40L expression and reduced mOX40 and mOX40L levels in T1D patients which correlated with the clinical characteristics and inflammatory factors. These results suggest that OX40/OX40L signal may be promising biomarkers and associated with the pathogenesis of T1D.

摘要

本研究分析了 T1D 患者中膜型 OX40 和 OX40L（mOX40 和 mOX40L）以及可溶性 OX40 和 OX40L（sOX40 和 sOX40L）的表达水平，以确定其临床意义。采集 T1D 患者和健康对照参与者的外周血（PB）。通过流式细胞术检测免疫细胞上 mOX40 和 mOX40L 的表达。通过 ELISA 测量血清中 sOX40 和 sOX40L 的水平。我们首次证明 T1D 患者的 sOX40 和 sOX40L 表达增强，mOX40 和 mOX40L 水平降低，这与临床特征和炎症因子有关。这些结果表明，OX40/OX40L 信号可能是有前途的生物标志物，并与 T1D 的发病机制有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/e25948be01d0/JIR2019-1780567.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/c62f03fb4158/JIR2019-1780567.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/ba0d6ec78795/JIR2019-1780567.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/8ab8e604dcc8/JIR2019-1780567.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/e25948be01d0/JIR2019-1780567.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/c62f03fb4158/JIR2019-1780567.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/ba0d6ec78795/JIR2019-1780567.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/8ab8e604dcc8/JIR2019-1780567.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9df6/6701347/e25948be01d0/JIR2019-1780567.004.jpg

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