Kelly J M
Department of Family Practice, Kaiser-Permanente, San Diego, CA 92120.
J Am Board Fam Pract. 1988 Oct-Dec;1(4):251-4.
Forty-four patients were studied for compliance in the use of their first prescription for sublingual nitroglycerin. Fourteen HMO physicians participated in this randomized, prospective study by administering the first dose to half the patients during the office visit in which the diagnosis of angina pectoris was made. No other changes were made in the physicians' customary methods of diagnosing and treating angina pectoris. Patients who received the demonstration dose were significantly more likely to have used the sublingual nitroglycerin at least once before their second visit (75 percent of the study group compared with 44 percent of the control group). There was no difference between the groups in having the drug with them at the second visit. While serious reactions to sublingual nitroglycerin are rare, 6 patients experienced symptoms from the first dose, including 1 patient who fainted. The results suggest that compliance in using the initial prescription for sublingual nitroglycerin can be improved when the physician supervises the first dose.
对44名患者首次舌下含服硝酸甘油处方的用药依从性进行了研究。14名健康维护组织（HMO）的医生参与了这项随机前瞻性研究，他们在诊断为心绞痛的门诊就诊时，给一半的患者服用了首剂药物。医生诊断和治疗心绞痛的常规方法没有其他改变。接受示范剂量的患者在第二次就诊前至少使用一次舌下含服硝酸甘油的可能性显著更高（研究组为75%，而对照组为44%）。两组患者在第二次就诊时随身携带药物的情况没有差异。虽然舌下含服硝酸甘油的严重不良反应很少见，但有6名患者在服用首剂后出现症状，其中1名患者晕厥。结果表明，当医生监督首剂用药时，舌下含服硝酸甘油初始处方的用药依从性可以得到提高。
