Department of Biomedical Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, Tamil Nadu, India.
Nanotechnology. 2019 Dec 13;30(50):502001. doi: 10.1088/1361-6528/ab3f17. Epub 2019 Aug 28.
Recently, magnetic nanoparticles (MNPs) based on manganite perovskites (LaSrMnO or LSMO) and/or spinel ferrites (i.e. SPFs with the formula MFeO; M=Co, Mg, Mn, Ni and Zn and mixed SPFs (e.g. Co-Zn, Mg-Mn, Mn-Zn and/or Ni-Zn)) have garnered great interest in magnetic hyperthermia therapy (MHT) as heat-inducing agents due to their tuneable magnetic properties including Curie temperature (T to generate controllable therapeutic temperatures (i.e. 42 °C-45 °C)-under the application of an alternating magnetic field (AMF)-for the treatment of cancer. In addition, these nanoparticles are also utilized in magnetic resonance imaging (MRI) as contrast-enhancing agents. However, the employment of the LSMO/SPF-based MNPs in these MHT/MRI applications is majorly influenced by their inherent properties, which are mainly tuned by the synthesis factors. Therefore, in this review article, we have systematically discussed the significant chemical methods used to synthesize the LSMO/SPF-based MNPs and their corresponding intrinsic physicochemical properties (size/shape/crystallinity/dispersibility) and/or magnetic properties (including saturation magnetization (M )/T ). Then, we have analyzed the usage of these MNPs for the effective imaging of cancerous tumors via MRI. Finally, we have reviewed in detail the heating capability (in terms of specific absorption rate) of the LSMO/SPF-based MNPs under calorimetric/biological conditions for efficient cancer treatment via MHT. Herein, we have mainly considered the significant parameters-such as size, surface coating (nature and amount), stoichiometry, concentration and the applied AMFs (including amplitude (H) and frequency (f))-that influence the heat induction ability of these MNPs.
最近，基于钙钛矿锰氧化物（LaSrMnO 或 LSMO）和/或尖晶石铁氧体（即具有化学式 MFeO 的 SPF；M=Co、Mg、Mn、Ni 和 Zn 和混合 SPF（例如 Co-Zn、Mg-Mn、Mn-Zn 和/或 Ni-Zn）的 MNPs 因其可调的磁性能（包括居里温度（T ），可在交变磁场（AMF）的作用下产生可控的治疗温度（即 42°C-45°C）），作为热诱导剂，在磁热疗（MHT）中引起了极大的兴趣，用于治疗癌症。此外，这些纳米粒子还用作磁共振成像（MRI）中的对比增强剂。然而，LSMO/SPF 基 MNPs 在这些 MHT/MRI 应用中的使用主要受到其固有特性的影响，这些特性主要由合成因素来调节。因此，在这篇综述文章中，我们系统地讨论了用于合成 LSMO/SPF 基 MNPs 的重要化学方法，以及它们的相应内在物理化学性质（尺寸/形状/结晶度/分散性）和/或磁性质（包括饱和磁化强度（M ）/T ）。然后，我们分析了这些 MNPs 在通过 MRI 对癌症肿瘤进行有效成像中的应用。最后，我们详细回顾了在热化学/生物学条件下，基于 LSMO/SPF 的 MNPs 的加热能力（以比吸收率表示），用于通过 MHT 进行有效的癌症治疗。在这里，我们主要考虑了影响这些 MNPs 热诱导能力的重要参数，例如尺寸、表面涂层（性质和数量）、化学计量比、浓度和施加的 AMF（包括幅度（H）和频率（f））。
