Obaidat Ihab M, Issa Bashar, Haik Yousef
Department of Physics, United Arab Emirates University, Al-Ain 15551, United Arab Emirates.
Department of Mechanical Engineering, United Arab Emirates University, Al-Ain 15555, United Arab Emirates.
Nanomaterials (Basel). 2015 Jan 9;5(1):63-89. doi: 10.3390/nano5010063.
Localized magnetic hyperthermia using magnetic nanoparticles (MNPs) under the application of small magnetic fields is a promising tool for treating small or deep-seated tumors. For this method to be applicable, the amount of MNPs used should be minimized. Hence, it is essential to enhance the power dissipation or heating efficiency of MNPs. Several factors influence the heating efficiency of MNPs, such as the amplitude and frequency of the applied magnetic field and the structural and magnetic properties of MNPs. We discuss some of the physics principles for effective heating of MNPs focusing on the role of surface anisotropy, interface exchange anisotropy and dipolar interactions. Basic magnetic properties of MNPs such as their superparamagnetic behavior, are briefly reviewed. The influence of temperature on anisotropy and magnetization of MNPs is discussed. Recent development in self-regulated hyperthermia is briefly discussed. Some physical and practical limitations of using MNPs in magnetic hyperthermia are also briefly discussed.
在小磁场作用下使用磁性纳米颗粒（MNPs）进行局部磁热疗是治疗小型或深部肿瘤的一种有前景的工具。为使该方法适用，应尽量减少MNPs的用量。因此，提高MNPs的功率耗散或加热效率至关重要。有几个因素会影响MNPs的加热效率，如外加磁场的幅度和频率以及MNPs的结构和磁性。我们将讨论一些有效加热MNPs的物理原理，重点关注表面各向异性、界面交换各向异性和偶极相互作用的作用。简要回顾了MNPs的基本磁性，如它们的超顺磁性行为。讨论了温度对MNPs各向异性和磁化强度的影响。简要讨论了自调节热疗的最新进展。还简要讨论了在磁热疗中使用MNPs的一些物理和实际限制。
