基于纸张的即时检测免疫分析：最新进展和新兴趋势。
Paper-based point-of-care immunoassays: Recent advances and emerging trends.
机构信息
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, PR China.
The Engineering and Application Laboratory of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Center of Chinese Medicine Engineering, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
出版信息
Biotechnol Adv. 2020 Mar-Apr;39:107442. doi: 10.1016/j.biotechadv.2019.107442. Epub 2019 Aug 27.
Immunoassay has been routinely used in hospitals and central labs. Nowadays, to further meet the requirement of widespread applications of immunoassays, it is urgently needed to produce a simplified, rapid and low-cost immunoassay to perform tests on site. To this end, paper-based point-of-care (POC) immunoassays have attracted intensive interests in recent years. In this paper, we present a comprehensive review of the recent advances and emerging trends of paper-based POC immunoassays, including the fundamental components and work principles, various detection mechanisms and applications, and existing commercialized devices/products. At last, we envision three promising development directions for paper-based POC immunoassays.
免疫测定已在医院和中心实验室中常规使用。如今，为了进一步满足免疫测定广泛应用的要求，迫切需要开发一种简化、快速且低成本的免疫测定方法，以便在现场进行测试。为此，近年来基于纸张的即时检测（POC）免疫测定引起了人们的浓厚兴趣。在本文中，我们全面回顾了基于纸张的 POC 免疫测定的最新进展和新兴趋势，包括基本组件和工作原理、各种检测机制和应用以及现有的商业化设备/产品。最后，我们展望了基于纸张的 POC 免疫测定的三个有前途的发展方向。
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