State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, Sichuan, 610041, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No.14, Sec. 3, Renminnan Road, Chengdu, Sichuan, 610041, China.
Eur J Med Chem. 2019 Nov 15;182:111620. doi: 10.1016/j.ejmech.2019.111620. Epub 2019 Aug 12.
Graphene quantum dots (GQDs) as novel nanomaterials, have received significant interest in the field of biomedical applications. It is worth noting that a large amount of research is devoted to GQDs-based nanocomposites for cancer treatment, especially for photodynamic therapy (PDT), in that they can act not only as more favorable photosensitizers (PSs) but also nanoplatforms for delivering PSs. In this review, the biological behavior and physicochemical properties of GQDs for PDT are described in detail, and the application of GQDs-based nanocomposites in improved PDT and PDT-based combination therapies is analyzed, which may provide a new strategy for designing efficient PDT systems for cancer treatment.
石墨烯量子点（GQDs）作为新型纳米材料，在生物医学应用领域引起了广泛关注。值得注意的是，大量研究致力于基于 GQDs 的纳米复合材料用于癌症治疗，特别是光动力疗法（PDT），因为它们不仅可以作为更理想的光敏剂（PS），还可以作为 PS 的纳米载体。本文详细描述了 GQDs 在 PDT 中的生物学行为和理化性质，并分析了基于 GQDs 的纳米复合材料在改进 PDT 和 PDT 联合治疗中的应用，这可能为设计用于癌症治疗的高效 PDT 系统提供新策略。
