Sami Samir, Stern Noah, Di Pierdomenico Andrew, Katz Brandon, Brock Gerald
Division of Urology, Department of Surgery, Western University, 268 Grosvenor Street, Room B4-663, London, ON N6A 4V2, Canada.
Medical School, University College Cork, College Road, T12 K8AF Cork, Ireland.
Med Sci (Basel). 2019 Aug 29;7(9):90. doi: 10.3390/medsci7090090.
Optimizing erectile dysfunction (ED) remains a clinically significant endeavor as insufficient outcomes from oral, injectable and even surgical approaches to treatment remain less than ideal. In this report, we integrate evolving knowledge and provide an algorithmic approach for the clinician to fine-tune management. We performed a PubMed and Medline search of Erectile Dysfunction treatment optimization, enhanced patient efficacy for ED, and why men fail ED treatment. All relevant papers for the past two decades were reviewed. Establishing the goals and objectives of the patient and partner while providing detailed instructions for treatment can minimize failures and create an environment that allows treatment optimization. A thorough work-up may identify reversible or contributing causes. We identified several areas where treatment of ED could be optimized. These include; management of associated medical conditions, lifestyle improvements, PDE5 inhibitor prescription strategies, management of hypogonadism and the initiation of intracavernosal injection therapy (ICI). In our view, once a man presents for help to the clinician, use of the simple strategies identified in this review to optimize the tolerability, safety and effectiveness of the selected treatment should result in enhanced patient and partner satisfaction, with improved outcomes.
优化勃起功能障碍(ED)的治疗仍然是一项具有临床重要意义的工作,因为口服、注射甚至手术治疗方法的效果仍不尽人意。在本报告中,我们整合了不断发展的知识,并为临床医生提供了一种算法方法来微调治疗管理。我们对PubMed和Medline进行了搜索,关键词为勃起功能障碍治疗优化、提高ED患者疗效以及男性ED治疗失败的原因。对过去二十年的所有相关论文进行了综述。在为患者及其伴侣设定目标和目的的同时,提供详细的治疗指导,可以将治疗失败率降至最低,并营造一个有利于治疗优化的环境。全面的检查可能会发现可逆或促成因素。我们确定了几个可以优化ED治疗的领域。这些领域包括:相关疾病的管理、生活方式的改善、PDE5抑制剂的处方策略、性腺功能减退的管理以及海绵体内注射疗法(ICI)的启动。我们认为,一旦男性向临床医生寻求帮助,采用本综述中确定的简单策略来优化所选治疗的耐受性、安全性和有效性,应能提高患者及其伴侣的满意度,并改善治疗效果。