从中国兜兰的根茎中分离得到的五个新的多羟基呋甾烷醇皂甙。
Five new polyhydroxylated furostanol saponins from the rhizomes of Tupistra chinensis.
机构信息
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China.
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
出版信息
Chin J Nat Med. 2019 Aug;17(8):624-630. doi: 10.1016/S1875-5364(19)30065-2.
Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J-N (1-5), together with four known furostanol saponins (6-9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC values of 72.5 ± 2.4 and 77.3 ± 2.5 μmol·L, respectively. Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC value of 88.6 ± 2.1 μmol·L.
从中国兜兰的根和根茎中分离得到了 5 个新的多羟基呋甾烷醇皂苷，并根据理化性质和光谱分析确定了它们的结构，分别为 tupistrosides J-N（1-5），此外还分离得到了 4 个已知的呋甾烷醇皂苷（6-9）。其中，化合物 3 和 5 对人结肠癌细胞系 SW620 的细胞毒活性分别为 72.5 ± 2.4 和 77.3 ± 2.5 μmol·L。化合物 4 对人肝癌细胞系 HepG2 的细胞毒活性为 88.6 ± 2.1 μmol·L。
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