从（Baker）N.Tanaka（同义词 Baker）的根和根茎中分离得到三种新的甾体皂苷。

Three new steroidal saponins from the roots and rhizomes of (Baker) N.Tanaka (synonym Baker).

机构信息

Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.

The Second Affiliated Hospital, Shaanxi University of Chinese Medicine, Xianyang, China.

出版信息

Nat Prod Res. 2021 Jan;35(1):108-115. doi: 10.1080/14786419.2019.1616723. Epub 2019 May 29.

DOI:10.1080/14786419.2019.1616723

PMID:31137985

Abstract

Three new steroidal saponins (-), together with four known compounds (-), were isolated from the roots and rhizomes of Baker, and their structures were determined as (24, 25 )-1-hydroxy-3-[(-D-glucopyranoside)oxy]-spirost-5-en-24-yl--D-glucopyranoside () and (24S)-spirost-25(27)-en-1, 3, 4, 5, 6, 24-hexahydroxy-24---D-glucopyranoside (), (22, 25S)1, 3, 4, 5, 26, 27-hexanol-furospirost-5, 26---D-glucopyranoside (), together with four known compounds 3-epi-diosgenin-3--D-glucopyranosid (), 3-epiruscogenin (), 25(R)-1-hydroxy-spirost-5-en-3-yl---D-glucopyranoside () and tupichinin A (), on the basis of physico-chemical properties and spectral analysis. In this study, compounds - and - were evaluated for their cytotoxic activity against SW620, A549 and HepG2 tumor cell lines. Among them, compound showed moderate cytotoxicity against two human cancer cell lines A549 and HepG 2 with IC values of 25.3 ± 2.6 and 26.1 ± 2.5 μM, respectively.

摘要

从 Baker 的根和根茎中分离得到三个新的甾体皂苷（-），以及四个已知化合物（-），并鉴定了它们的结构为（24,25）-1-羟基-3-[-（-D-吡喃葡萄糖苷）氧基]-螺甾-5-烯-24-yl--D-吡喃葡萄糖苷（）和（24S）-螺甾-25（27）-烯-1,3,4,5,6,24-六羟基-24---D-吡喃葡萄糖苷（），（22,25S）1,3,4,5,26,27-六醇-呋喃螺甾-5,26---D-吡喃葡萄糖苷（），与四个已知化合物 3-表-薯蓣皂苷元-3--D-吡喃葡萄糖苷（），3-鲁斯可皂苷元（），25（R）-1-羟基-螺甾-5-烯-3-yl---D-吡喃葡萄糖苷（）和 tupichinin A（），基于物理化学性质和光谱分析。在这项研究中，对化合物 - 和 - 进行了细胞毒性活性评价，针对 SW620、A549 和 HepG2 肿瘤细胞系。其中，化合物对两种人癌细胞系 A549 和 HepG2 显示出中等的细胞毒性，IC 值分别为 25.3±2.6 和 26.1±2.5 μM。