治疗胆道和肝脏肿瘤的非手术方法

Nonsurgical Approaches to Treat Biliary Tract and Liver Tumors.

作者信息

Green Benjamin L, House Michael G

机构信息

Department of Surgery, Indiana University School of Medicine-IU Health University Hospital, 545 Barnhill Drive, Emerson Hall 515, Indianapolis, IN 46202, USA.

出版信息

Surg Oncol Clin N Am. 2019 Oct;28(4):573-586. doi: 10.1016/j.soc.2019.06.013.

DOI:10.1016/j.soc.2019.06.013

PMID:31472906

Abstract

Endoscopic and percutaneous therapies have been shown to prolong life and reduce morbidity for patients with unresectable advanced stages of primary hepatobiliary malignancies. This article reviews pertinent studies published within the last 5 years that involve locoregional techniques to manage hepatocellular carcinoma, perihilar and distal cholangiocarcinoma. A major emphasis is placed on photodynamic therapy, radiofrequency ablation, irreversible electroporation, and microwave ablation. Technical advances, combinational therapies, and postintervention outcomes are discussed. Despite widespread application, high-quality evidence does not show superiority of any particular locoregional technique for treating advanced hepatobiliary cancers.

摘要

内镜治疗和经皮治疗已被证明可延长不可切除的晚期原发性肝胆恶性肿瘤患者的生命并降低其发病率。本文回顾了过去5年内发表的相关研究，这些研究涉及用于治疗肝细胞癌、肝门部和远端胆管癌的局部区域技术。重点讨论了光动力疗法、射频消融、不可逆电穿孔和微波消融。文中还讨论了技术进展、联合治疗以及干预后的结果。尽管这些技术已广泛应用，但高质量证据并未表明任何一种特定的局部区域技术在治疗晚期肝胆癌方面具有优越性。