Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, United States.
Cell & Molecular Biology, Biology, Boston University, United States.
Curr Opin Virol. 2019 Oct;38:89-96. doi: 10.1016/j.coviro.2019.07.011. Epub 2019 Aug 29.
Despite the success of antiretroviral therapies, there is no cure for HIV-1 infection due to the establishment of a long-lived latent reservoir that fuels viral rebound upon treatment interruption. 'Shock-and-kill' strategies to diminish the latent reservoir have had modest impact on the reservoir leading to considerations of alternative approaches to target HIV-1 proviruses. This review explores approaches to target HIV-1 transcription as a way to block the provirus expression.
尽管抗逆转录病毒疗法取得了成功，但由于建立了一个长期存在的潜伏储库，使得病毒在治疗中断后会反弹，因此 HIV-1 感染仍然无法治愈。“震撼和杀伤”策略旨在减少潜伏储库，但对储库的影响有限，因此人们开始考虑采用其他方法来靶向 HIV-1 前病毒。本文探讨了靶向 HIV-1 转录作为阻断前病毒表达的一种方法。
