Chen Yu-Chih, Aui Shin-Peir, Lai Yin-Siew, Chang Ko-Tung
Graduate Institute of Bioresources, National Pingtung University of Science and Technology, Neipu, Taiwan.
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Neipu, Taiwan.
Int J Stem Cells. 2019 Nov 30;12(3):381-387. doi: 10.15283/ijsc19048.
Space traveling is imperative for mankind in the future. Expectedly, hibernation will become an option for space traveler to overcome the endless voyage. With regard to some of the studies pointed out that during hibernation, muscle will undergo atrophy and meantime neurogenesis will reduce, these obstacles were frequently related with stem cell regeneration. Thus, investigation on whether hibernation will lead to dysfunction of stem cell becomes an important issue. By going through four main systems in this article, such as, hematopoietic system, skeletal muscle system, central nervous system and orthopedic system, we are expecting that stem cells regeneration capacity will be affected by hibernation. To date, these researches are majorly the read-out from short term or seasonal hibernating mammals. Proposing and creating a simulated long-term hibernation animal model is turning essential for the further investigation on the effect of longer period of hibernation to human stem cells.
太空旅行对人类未来而言势在必行。可以预见，冬眠将成为太空旅行者克服漫长旅程的一种选择。关于一些研究指出，在冬眠期间，肌肉会发生萎缩，同时神经发生会减少，这些障碍常常与干细胞再生有关。因此，研究冬眠是否会导致干细胞功能障碍成为一个重要问题。通过本文阐述造血系统、骨骼肌系统、中枢神经系统和骨科系统这四个主要系统，我们期望干细胞再生能力会受到冬眠的影响。迄今为止，这些研究主要是从短期或季节性冬眠的哺乳动物中得出的结果。提出并创建一个模拟长期冬眠的动物模型对于进一步研究更长时间的冬眠对人类干细胞的影响变得至关重要。
