Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Phytother Res. 2019 Dec;33(12):3153-3162. doi: 10.1002/ptr.6487. Epub 2019 Sep 1.
The aim of the present randomized controlled trial was to evaluate the effect of a micronized resveratrol supplement on glycemic status, lipid profile, and body composition in patients with type 2 diabetes mellitus (T2DM). A total of 71 overweight patients with T2DM (body mass index ranged 25-30) were randomly assigned to receive 1000 mg/day trans-resveratrol or placebo (methyl cellulose) for 8 weeks. Anthropometric indices and biochemical indices including lipid and glycemic profile were measured before and after the intervention. In adjusted model (age, sex, and baseline body mass index), resveratrol decreased fasting blood sugar (-7.97±13.6 mg/dL, p=0.05) and increased high density lipoprotein (3.62±8.75 mg/dL, p=0.01) levels compared with placebo. Moreover, the mean difference in insulin levels reached significance (-0.97±1.91, μIU/mL, p= 0.02). However, no significant differences were observed for anthropometric measures. It was found that 8-week resveratrol supplementation produced useful effects on some cardio-metabolic parameters in patients with T2DM. More studies are needed to confirm these findings.
本随机对照试验旨在评估补充白藜芦醇对 2 型糖尿病（T2DM）患者血糖状况、血脂谱和身体成分的影响。共纳入 71 名超重 T2DM 患者（体重指数范围为 25-30），随机分为每日 1000 毫克反式白藜芦醇组或安慰剂（甲基纤维素）组，干预 8 周。在干预前后测量了人体测量指数和生化指数，包括血脂谱和血糖谱。在调整模型（年龄、性别和基线体重指数）后，与安慰剂相比，白藜芦醇降低了空腹血糖（-7.97±13.6mg/dL，p=0.05）并增加了高密度脂蛋白（3.62±8.75mg/dL，p=0.01）水平。此外，胰岛素水平的平均差异具有显著性（-0.97±1.91μIU/mL，p=0.02）。然而，人体测量指标没有观察到显著差异。研究发现，补充 8 周白藜芦醇对 T2DM 患者的一些心血管代谢参数有有益的影响。需要更多的研究来证实这些发现。
