College of Health Solutions, Arizona State University, Phoenix, Arizona.
College of Health Solutions, Arizona State University, Phoenix, Arizona.
J Adolesc Health. 2020 Feb;66(2):166-171. doi: 10.1016/j.jadohealth.2019.06.005. Epub 2019 Aug 30.
The transition to college is a vulnerable period for weight gain and the onset of obesity. Gut microbes differ in obese compared with lean individuals, but gut microbiota in adolescent-aged college freshmen during a known period of weight gain have never been studied. This pre-post observational pilot study assessed associations between intestinal microbiota changes and weight-related outcomes in healthy adolescent college freshmen living in on-campus dormitories at Arizona State University (n = 39).
We measured anthropometrics (waist circumference [WC], height, weight, and body mass index [BMI]) and collected fecal samples at the beginning and end of the 2015-2016 academic year. Fold changes in species-level microbes across time were measured by quantitative real-time polymerase chain reaction and used in correlation and multivariate regression analyses.
A total of 24 female and 15 male adolescents (aged 18.54 ± .67 years) participated in this study. Over the academic year, BMI and WC increased by .97±1.28 kg/m and 2.64±4.90 cm, respectively. Correlation analyses indicated a significant negative association between Akkermansia muciniphila and both percentage WC change and percentage BMI change (r = -.66, p < .01; and r = -.33, p = .04, respectively). Multivariate regression analysis controlling for sociodemographics showed a significant association between A. muciniphila and percentage WC change, but not percentage BMI change (R = .53, p < .01; and R = .24, p = .15, respectively).
As this was the first study in a university-based adolescent population to show a relationship between A. muciniphila and weight-related outcomes, further research is needed to explore these findings.
进入大学是体重增加和肥胖开始的脆弱时期。与瘦人相比，肥胖者的肠道微生物不同，但在已知的体重增加期间，青少年大学生的肠道微生物群从未被研究过。本前瞻性观察性试点研究评估了亚利桑那州立大学（ASU）校内宿舍居住的健康青少年大学生肠道微生物变化与与体重相关的结局之间的关联（n=39）。
我们在 2015-2016 学年开始和结束时测量了人体测量学（腰围[WC]、身高、体重和体重指数[BMI]）并收集了粪便样本。通过定量实时聚合酶链反应测量物种水平微生物在时间上的变化倍数，并用于相关性和多变量回归分析。
共有 24 名女性和 15 名男性青少年（年龄 18.54±0.67 岁）参与了这项研究。在整个学年中，BMI 和 WC 分别增加了 0.97±1.28kg/m 和 2.64±4.90cm。相关性分析表明，Akkermansia muciniphila 与 WC 百分比变化和 BMI 百分比变化呈显著负相关（r=-.66，p<0.01；r=-.33，p=0.04）。控制社会人口统计学因素的多变量回归分析显示，A. muciniphila 与 WC 百分比变化显著相关，但与 BMI 百分比变化不相关（R=0.53，p<0.01；R=0.24，p=0.15）。
由于这是第一项在基于大学的青少年人群中研究 A. muciniphila 与体重相关结局之间关系的研究，因此需要进一步研究来探讨这些发现。
