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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sarno E N, Espinosa M, Sampaio E P, Vieira L M, Figueiredo A A, Miranda C F, Esquenazi D, Salgado J L, Nogueira N

Laboratório de Hanseníase, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

Braz J Med Biol Res. 1988;21(3):461-70.

The cellular immune response to M. leprae and BCG antigens was evaluated in 98 leprosy patients and 143 household contacts lacking clinical manifestation of the disease. 2. The proliferative responses and release of Interferon-gamma by peripheral blood mononuclear cells were assessed and both patients and contacts were classified as low or high responders to M. leprae. 3. The high responder contacts constituted 54.8% of the population analyzed, a three times higher proportion when compared to the controls, indicating the possible existence of active infection among them. 4. The correlation coefficient between the immunological response to M. leprae and BCG was found to be higher within the contact group than in the patients, suggesting that cross-reactivity defense mechanisms against mycobacteria exist even before the onset of clinically detectable disease.

对98例麻风病患者和143名无该病临床表现的家庭接触者评估了对麻风杆菌和卡介苗抗原的细胞免疫反应。2. 对外周血单核细胞的增殖反应和γ干扰素释放进行了评估，患者和接触者均被分类为对麻风杆菌的低反应者或高反应者。3. 高反应性接触者占所分析人群的54.8%，与对照组相比比例高出三倍，表明他们中可能存在活动性感染。4. 发现接触者组内对麻风杆菌和卡介苗的免疫反应之间的相关系数高于患者组，这表明在临床可检测疾病发作之前就存在针对分枝杆菌的交叉反应防御机制。

Sarno E N, Espinosa M, Sampaio E P, Vieira L M, Figueiredo A A, Miranda C F, Esquenazi D, Salgado J L, Nogueira N

Laboratório de Hanseníase, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

Braz J Med Biol Res. 1988;21(3):461-70.

The cellular immune response to M. leprae and BCG antigens was evaluated in 98 leprosy patients and 143 household contacts lacking clinical manifestation of the disease. 2. The proliferative responses and release of Interferon-gamma by peripheral blood mononuclear cells were assessed and both patients and contacts were classified as low or high responders to M. leprae. 3. The high responder contacts constituted 54.8% of the population analyzed, a three times higher proportion when compared to the controls, indicating the possible existence of active infection among them. 4. The correlation coefficient between the immunological response to M. leprae and BCG was found to be higher within the contact group than in the patients, suggesting that cross-reactivity defense mechanisms against mycobacteria exist even before the onset of clinically detectable disease.

对98例麻风病患者和143名无该病临床表现的家庭接触者评估了对麻风杆菌和卡介苗抗原的细胞免疫反应。2. 对外周血单核细胞的增殖反应和γ干扰素释放进行了评估，患者和接触者均被分类为对麻风杆菌的低反应者或高反应者。3. 高反应性接触者占所分析人群的54.8%，与对照组相比比例高出三倍，表明他们中可能存在活动性感染。4. 发现接触者组内对麻风杆菌和卡介苗的免疫反应之间的相关系数高于患者组，这表明在临床可检测疾病发作之前就存在针对分枝杆菌的交叉反应防御机制。