Karki Diksha, Upadhyaya Paricha, Adhikari Purbesh, Dahal Mona, Thapa Bishow Prakash Jung, Mudhbari Bandana, Lama Gopal, Pathak Neera
Department of Pathology, BP Koirala Institute of Health Sciences, Dharan, Nepal.
JNMA J Nepal Med Assoc. 2019 May-Jun;57(217):202-205. doi: 10.31729/jnma.4455.
Leiomyosarcoma of inferior venacava is a rare tumor. Female are most commonly affected and middle segment of inferior vena cava is the commonest site. The diagnosis can sometimes be challenging as patients present with non-specific symptoms. We present a case of a 65-year-old female who presented with pain in right hypochondrium and epigastric region since 4 months along with weight loss, anorexia and vomiting. Histopathological examination revealed a capsulated, multilobated tumor arising from muscle layer of inferior venacava with extraluminal growth pattern and tumor cells showing cytoplasmic positivity for immuno-histochemical stain smooth muscle actin. With the diagnosis of leiomyosarcoma of inferior venacava, excision of tumor was done with tangential excision of 4 cm length of inferior venacava with primary repair. Keywords: inferior venacava; leiomyosarcoma; smooth muscle actin.
下腔静脉平滑肌肉瘤是一种罕见的肿瘤。女性最常受累,下腔静脉中段是最常见的部位。由于患者表现出非特异性症状,诊断有时具有挑战性。我们报告一例65岁女性,自4个月以来出现右季肋部和上腹部疼痛,伴有体重减轻、厌食和呕吐。组织病理学检查显示,肿瘤有包膜,多叶状,起源于下腔静脉肌层,呈腔外生长模式,肿瘤细胞免疫组化染色平滑肌肌动蛋白呈细胞质阳性。诊断为下腔静脉平滑肌肉瘤后,行肿瘤切除,同时对4厘米长的下腔静脉进行切线切除并一期修复。关键词:下腔静脉;平滑肌肉瘤;平滑肌肌动蛋白