Key Laboratory of Pediatrics in Chongqing, Chongqing, 400014, People's Republic of China.
Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, 400014, People's Republic of China.
Clin Exp Med. 2019 Nov;19(4):457-462. doi: 10.1007/s10238-019-00577-4. Epub 2019 Sep 3.
The purpose of this study was to examine the serum levels of fibroblast growth factor 21 (FGF21) in children with acute Kawasaki disease (KD) and to investigate its relationship with coronary artery lesions (CALs). Blood samples from 58 children with KD before intravenous immunoglobulin treatment and from 28 healthy children as control group were collected. Serum FGF21 levels in all participants were measured using enzyme-linked immunosorbent assay, and clinical parameters were tested in all KD patients. Serum FGF21 levels were significantly increased in acute KD patients as compared to the control group. Serum levels of FGF21 were substantially higher in the group of KD patients with CALs (KD-CALs) than in KD patients without CALs (KD-NCALs). Positive relationships between serum levels of FGF21 and percentage of leukomonocytes (L %), C-reactive protein, activated partial thromboplastin time and D-dimer were observed in KD patients. Furthermore, serum FGF21 levels were negatively correlated with red blood cell counts, hemoglobin (Hb), percentage of neutrophils (N %) and albumin. Serum level of FGF21 is associated with inflammation and coagulation. The paradoxical increase in serum FGF21 in acute KD patients may indicate a protective compensatory response.
本研究旨在检测急性川崎病（KD）患儿血清成纤维细胞生长因子 21（FGF21）水平，并探讨其与冠状动脉病变（CALs）的关系。收集了 58 例接受静脉注射免疫球蛋白治疗前的 KD 患儿和 28 例健康儿童作为对照组的血液样本。采用酶联免疫吸附试验测定所有参与者的血清 FGF21 水平，并对所有 KD 患儿进行临床参数检测。与对照组相比，急性 KD 患儿的血清 FGF21 水平明显升高。有冠状动脉病变（KD-CALs）的 KD 患儿组的血清 FGF21 水平明显高于无冠状动脉病变（KD-NCALs）的 KD 患儿组。在 KD 患儿中，血清 FGF21 水平与白细胞百分比（L%）、C 反应蛋白、活化部分凝血活酶时间和 D-二聚体呈正相关。此外，血清 FGF21 水平与红细胞计数、血红蛋白（Hb）、中性粒细胞百分比（N%）和白蛋白呈负相关。血清 FGF21 水平与炎症和凝血有关。急性 KD 患儿血清 FGF21 的反常增加可能表明存在一种保护性代偿反应。
