Xu Sheng, Wang Kuai, Kong Wangqing
The Center for Precision Synthesis (CPS), Institute for Advanced Studies (IAS) , Wuhan University , Wuhan 430072 , People's Republic of China.
Org Lett. 2019 Sep 20;21(18):7498-7503. doi: 10.1021/acs.orglett.9b02788. Epub 2019 Sep 3.
An easy-to-handle Ni-catalyzed three-component reductive arylacylation of alkenes using isobutyl chloroformate as a CO source was described. This reaction operates under mild reaction conditions without the need to use toxic CO gas or metal carbonyl reagents. In addition, this method allows for rapid synthesis of 3,3-disubstituted oxindoles with an all-carbon quaternary stereocenter containing a ketone group in good yields with broad substrate scope.
描述了一种易于操作的镍催化的烯烃三组分还原芳基酰化反应，该反应使用氯甲酸异丁酯作为CO源。该反应在温和的反应条件下进行，无需使用有毒的CO气体或金属羰基试剂。此外，该方法能够快速合成具有全碳季碳立体中心且含有酮基的3,3-二取代氧化吲哚，产率良好，底物范围广泛。
