Department of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.
Department of Cardiac Surgery, University of Michigan, Ann Arbor, Michigan.
Ann Thorac Surg. 2020 Apr;109(4):1227-1232. doi: 10.1016/j.athoracsur.2019.07.035. Epub 2019 Aug 31.
Despite guideline recommendations, rates of concomitant tricuspid valve repair are suboptimal, possibly due to fear of complications. We reviewed morbidity, mortality, recurrent tricuspid regurgitation, and right ventricular remodeling after guideline-directed concomitant tricuspid valve repair.
We performed guideline-directed concomitant tricuspid valve repair on 171 consecutive patients who underwent left-sided valve surgery (degenerative mitral surgery or aortic valve replacement) between May 2012 and March 2016. Exclusion criteria included functional mitral regurgitation, rheumatic disease, active endocarditis, and concomitant coronary artery bypass grafting or complex aortic surgery.
Mean age was 68 ± 12 years, and 47% (81 of 171) were women. Preoperative atrial fibrillation was present in 57% (98 of 171), and preoperative tricuspid regurgitation was moderate or higher in 64% (108 of 171). The rate of de novo pacemaker placement was 4.1% (7 of 171), and the 30-day mortality rate was 0.6% (1 of 171). Estimated survival was 95% ± 4% at 1 year and 92% ± 5% at 5 years. Freedom from moderate or worse residual/recurrent tricuspid regurgitation was 93% ± 6% at 6 months and 89% ± 8% at 3 years. Quantitative echocardiography found no significant increase in right ventricular dimensions or area at 1 year in subgroup analysis. Mean echocardiographic follow-up was 14.1 months, and mean clinical follow-up was 33.9 months.
Guideline-directed concomitant tricuspid valve repair resulted in excellent safety end points and survival. At 14 months, freedom from moderate or worse tricuspid regurgitation was high, right ventricular performance did not worsen, and the pacemaker rate was comparable to rates after isolated mitral repair. Given these findings, adherence to current guidelines regarding functional tricuspid regurgitation should be encouraged.
尽管有指南建议,但同时进行三尖瓣修复的比例并不理想,这可能是由于担心并发症。我们回顾了指南指导下同期行三尖瓣修复术患者的发病率、死亡率、复发性三尖瓣反流和右心室重构情况。
我们对 2012 年 5 月至 2016 年 3 月间行左侧瓣膜手术(退行性二尖瓣手术或主动脉瓣置换术)的 171 例连续患者进行了指南指导下同期行三尖瓣修复术。排除标准包括功能性二尖瓣反流、风湿性疾病、活动性心内膜炎以及同期行冠状动脉旁路移植术或复杂主动脉手术。
平均年龄为 68 ± 12 岁,47%(171 例中的 81 例)为女性。术前心房颤动占 57%(171 例中的 98 例),术前三尖瓣反流中度或以上占 64%(171 例中的 108 例)。新置起搏器的发生率为 4.1%(171 例中的 7 例),30 天死亡率为 0.6%(171 例中的 1 例)。估计 1 年生存率为 95%±4%,5 年生存率为 92%±5%。6 个月时中度或以上残余/复发性三尖瓣反流的无事件生存率为 93%±6%,3 年时为 89%±8%。亚组分析发现,定量超声心动图在 1 年内右心室大小或面积无明显增加。平均超声心动图随访时间为 14.1 个月,平均临床随访时间为 33.9 个月。
指南指导下同期行三尖瓣修复术的安全性和存活率均良好。在 14 个月时,中度或以上三尖瓣反流的无事件生存率较高,右心室功能没有恶化,起搏器的发生率与单独二尖瓣修复术相当。鉴于这些发现,应鼓励遵循当前有关功能性三尖瓣反流的指南。