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三尖瓣修复对因风湿性疾病接受二尖瓣手术患者手术死亡的影响。

Impact of Tricuspid Repair on Surgical Death in Patients Undergoing Mitral Valve Surgery Due to Rheumatic Disease.

作者信息

Santana Gustavo P, Vieira de Melo Rodrigo M, Viana Tainá T, N Velame da Silva Daniela, Figueiredo Clara S, de Azevedo Diogo F C, Junior Osvaldemar R N, Câmara Edmundo J N, Damasceno Luanna M, Silva Ana Luísa A A, Granja João Pedro M M, Passos Luiz C S

机构信息

Ana Nery Hospital, Cardiology Department, Salvador-BA, Brazil.

Federal University of Bahia, Salvador-BA, Brazil.

出版信息

Struct Heart. 2024 Apr 4;8(4):100298. doi: 10.1016/j.shj.2024.100298. eCollection 2024 Jul.

Abstract

BACKGROUND

Tricuspid valve repair during mitral valve replacement surgery remains a controversial topic. The risk-benefit ratio in some populations remains uncertain, especially in rheumatic heart disease patients. Therefore, we aimed to evaluate the impact of concomitant tricuspid repair on surgical mortality in patients undergoing cardiac surgery due to rheumatic mitral valve disease who have moderate to severe functional tricuspid regurgitation.

METHODS

This is a prospective cohort study from January 1, 2017, to December 30, 2022. All patients over 18 years of age who underwent cardiac surgery to correct rheumatic mitral valve disease with concomitant moderate to severe tricuspid regurgitation were included. The primary outcome was a surgical death. In an exploratory analysis, clinical and echocardiographic data were obtained 2 years after the procedure.

RESULTS

Of the 144 patients included, 83 (57.6%) underwent tricuspid valve repair. The mean age was 46.2 (±12.3) years with 107 (74.3%) female individuals, the median left ventricular ejection fraction was 61.0% (55-67), and systolic pulmonary artery pressure (sPAP) was 55.0 mmHg (46-74), with 45 (31.3%) individuals with right ventricular dysfunction. The total in-hospital mortality was 15 (10.4%) individuals, and there was no difference between the groups submitted or not to tricuspid repair: 10 (12.0%) vs. 5 (7.5%); = 0.46, respectively. There was an association with one variable independently: the sPAP value, relative risk 1.04 (1.01-1.07), = 0.01. The estimated cut-off value of sPAP that indicates higher early mortality through the receiver operating characteristic curve (area 0.70, = 0.012) was 73.5 mmHg.

CONCLUSIONS

Performing tricuspid repair in individuals who were undergoing cardiac surgery to correct rheumatic mitral valve disease was not associated with increased surgical mortality. Our results suggest the safety of tricuspid repair even in this high-risk population, reinforcing the recommendations in current guidelines.

摘要

背景

二尖瓣置换手术期间的三尖瓣修复仍是一个有争议的话题。在某些人群中,风险效益比仍不确定,尤其是在风湿性心脏病患者中。因此,我们旨在评估对于因风湿性二尖瓣疾病而接受心脏手术且伴有中重度功能性三尖瓣反流的患者,同期进行三尖瓣修复对手术死亡率的影响。

方法

这是一项从2017年1月1日至2022年12月30日的前瞻性队列研究。纳入所有18岁以上因风湿性二尖瓣疾病接受心脏手术且伴有中重度三尖瓣反流的患者。主要结局是手术死亡。在一项探索性分析中,术后2年获取临床和超声心动图数据。

结果

在纳入的144例患者中,83例(57.6%)接受了三尖瓣修复。平均年龄为46.2(±12.3)岁,女性107例(74.3%),左心室射血分数中位数为61.0%(55 - 67),收缩期肺动脉压(sPAP)为55.0 mmHg(46 - 74),45例(31.3%)患者存在右心室功能障碍。院内总死亡率为15例(10.4%),接受或未接受三尖瓣修复的组间无差异:分别为10例(12.0%)对5例(7.5%);P = 0.46。有一个变量与之独立相关:sPAP值,相对风险1.04(1.01 - 1.07),P = 0.01。通过受试者工作特征曲线(曲线下面积0.70,P = 0.012)得出的提示早期死亡率较高的sPAP估计临界值为73.5 mmHg。

结论

对于因风湿性二尖瓣疾病接受心脏手术的患者进行三尖瓣修复与手术死亡率增加无关。我们的结果表明即使在这个高危人群中三尖瓣修复也是安全的,强化了当前指南中的建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e809/11294826/e2fe3a75a6f7/gr1.jpg

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