Cao Nengneng, Li Jinlan, Ling Chun, Wang Jiajia, An Furun
Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Anhui Medical University, Hefei, Anhui, China.
Front Nutr. 2025 Feb 17;12:1538696. doi: 10.3389/fnut.2025.1538696. eCollection 2025.
Diabetes mellitus (DM) has emerged as a significant component of the global health crisis, closely linked with anemia. Studies have demonstrated a connection between anemia and inflammation. The Dietary Inflammatory Index (DII) is a novel metric for evaluating the overall inflammatory or anti-inflammatory impact of dietary intake. While risk factors for DM are linked to an unhealthy diet, there is currently insufficient research regarding the correlation between DII and anemia among individuals with DM. This study aims to investigate the correlation between DII and anemia among American individuals with DM.
This study utilized data from the National Health and Nutrition Examination Survey (NHANES) database, encompassing 4,435 participants recorded between 2007 and 2016. We conducted a weighted multivariable logistic regression analysis to investigate the correlation between the DII and anemia of individuals with DM. Furthermore, we explored their relationship through subgroup analysis and smooth curve fitting techniques.
This study comprised 726 participants with DM who were anemic and 3,709 who were non-anemic; notably, anemic participants exhibited elevated DII scores (2.05 ± 1.50 vs. 1.70 ± 1.59). In the fully adjusted model, we noted a positive correlation between the DII and anemia (Odds Ratio [OR] = 1.09, 95% Confidence Interval [CI] =1.03 to 1.16, = 0.004). Participants in the fully adjusted model had a 9% higher prevalence of anemia for each unit increase in DII. The significant association between anemia and DII persisted even after subgroup analysis. Smooth curve fitting analysis revealed a positive correlation between DII and anemia.
There is a positive correlation between DII and anemia in individuals with DM in the United States. It provides important insights into dietary management strategies for diabetic patients with anemia.
糖尿病已成为全球健康危机的一个重要组成部分，与贫血密切相关。研究表明贫血与炎症之间存在联系。饮食炎症指数（DII）是一种用于评估饮食摄入的总体炎症或抗炎影响的新指标。虽然糖尿病的危险因素与不健康饮食有关，但目前关于糖尿病患者中DII与贫血之间的相关性研究不足。本研究旨在调查美国糖尿病患者中DII与贫血之间的相关性。
本研究利用了国家健康与营养检查调查（NHANES）数据库中的数据，涵盖了2007年至2016年期间记录的4435名参与者。我们进行了加权多变量逻辑回归分析，以研究糖尿病患者中DII与贫血之间的相关性。此外，我们通过亚组分析和平滑曲线拟合技术探索了它们之间的关系。
本研究包括726名贫血的糖尿病参与者和3709名非贫血的糖尿病参与者；值得注意的是，贫血参与者的DII得分较高（2.05±1.50对1.70±1.59）。在完全调整模型中，我们注意到DII与贫血之间存在正相关（优势比[OR]=1.09，95%置信区间[CI]=1.03至1.16，P=0.004）。在完全调整模型中，DII每增加一个单位，贫血患病率就会高出9%。即使在亚组分析后，贫血与DII之间的显著关联仍然存在。平滑曲线拟合分析显示DII与贫血之间存在正相关。
在美国糖尿病患者中，DII与贫血之间存在正相关。这为贫血糖尿病患者的饮食管理策略提供了重要见解。
