Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.
J Nutr. 2023 Jun;153(6):1783-1792. doi: 10.1016/j.tjnut.2023.04.015. Epub 2023 Apr 19.
Dietary patterns related to inflammation have become a focus of disease prevention but the patterns may vary among populations.
The study was conducted to determine Taiwanese dietary inflammatory patterns and evaluate their associations with biomarkers of lipid and glucose.
Data were taken from 5664 community-dwelling individuals aged ≥55 y recruited in 2009-2013 in the Healthy Aging Longitudinal Study in Taiwan (HALST). Dietary data were obtained from an FFQ. An empirical dietary inflammatory pattern (EDIP) was derived from reduced rank regression models that explained the serum high-sensitivity CRP, plasma IL-6, and TNF receptor 1. Cross-sectional associations between dietary scores and biomarkers of total cholesterol (TC); HDL cholesterol; LDL cholesterol; TG; and ratios of TG/HDL cholesterol, TG/TC, fasting glucose, insulin, and HbA1c were analyzed via multiple linear regression and adjusted for major confounders. The false-discovery rate (FDR)-adjusted P < 0.05 was considered statistically significant. Abdominal obesity was defined as a waist circumference of ≥90 cm for men and ≥80 cm for women.
Higher EDIP-HALST scores were associated with higher TG (per score increment: 1.62%, 95% CI: 0.58%, 2.76%; P = 0.01), TG/HDL cholesterol (2.01%, 95% CI: 0.67%, 3.37%; P = 0.01), and TG/TC (1.42%, 95% CI: 0.41%, 2.43%; P = 0.01) and nonlinearly associated with insulin, with those in the middle tertile had the highest serum insulin concentrations (means: 5.12 μIU/mL, 95% CI: 4.78, 5.78; P = 0.04) in men, but not in women. No heterogeneity was detected between sexes. The associations with TG (1.23%, 95% CI: 0.19, 2.23%; P = 0.02), TG/HDL cholesterol (1.62%, 95% CI: 0.30%, 2.96%; P = 0.02), and TG/TC (1.11%, 95% CI: 0.11%, 2.13%; P = 0.03) were stronger in participants with abdominal obesity, but were borderline associated in participants with normal abdominal circumferences (all P = 0.05).
Inflammatory diets, as measured via EDIP-HALST, are associated with serum TG concentration, particularly in participants with abdominal obesity. These findings may suggest that developing disease prevention strategies using dietary inflammatory patterns may be different by populations. J Nutr 20xx;x:xx.
与炎症相关的饮食模式已成为疾病预防的重点，但不同人群的模式可能不同。
本研究旨在确定台湾的饮食炎症模式，并评估其与脂质和葡萄糖生物标志物的相关性。
数据来自 2009-2013 年在台湾健康老龄化纵向研究（HALST）中招募的 5664 名≥55 岁的社区居民。饮食数据来自 FFQ。通过解释血清高敏 CRP、血浆 IL-6 和 TNF 受体 1 的降秩回归模型得出经验性饮食炎症模式（EDIP）。通过多元线性回归分析，对饮食评分与总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、TG/HDL-C、TG/TC、空腹血糖、胰岛素和 HbA1c 等生物标志物之间的横断面相关性进行分析，并调整了主要混杂因素。经错误发现率（FDR）校正后 P < 0.05 被认为具有统计学意义。腹部肥胖定义为男性腰围≥90cm，女性腰围≥80cm。
较高的 EDIP-HALST 评分与较高的 TG（每评分增加：1.62%，95%CI：0.58%，2.76%；P=0.01）、TG/HDL-C（2.01%，95%CI：0.67%，3.37%；P=0.01）和 TG/TC（1.42%，95%CI：0.41%，2.43%；P=0.01）呈正相关，并与胰岛素呈非线性相关，其中中间三分位组的血清胰岛素浓度最高（平均值：5.12μIU/mL，95%CI：4.78，5.78；P=0.04），但在女性中则不然。男女之间没有发现异质性。在腹部肥胖者中，TG（1.23%，95%CI：0.19%，2.23%；P=0.02）、TG/HDL-C（1.62%，95%CI：0.30%，2.96%；P=0.02）和 TG/TC（1.11%，95%CI：0.11%，2.13%；P=0.03）的相关性更强，但在腹部正常围度者中呈边缘相关（所有 P=0.05）。
通过 EDIP-HALST 测量的炎症饮食与血清 TG 浓度有关，特别是在腹部肥胖者中。这些发现可能表明，使用饮食炎症模式制定疾病预防策略在不同人群中可能有所不同。
