Shademan Behrouz, Nourazarian Alireza, Laghousi Delara, Karamad Vahidreza, Nikanfar Masoud
Department of Medical Biology, Faculty of Medicine, EGE University, Izmir, Turkey.
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
J Clin Lab Anal. 2021 Sep 7;35(10):e23996. doi: 10.1002/jcla.23996.
Stroke is the second leading cause of death worldwide with heterogeneous characteristics. The subtypes of stroke are due to different pathophysiological regulations and causes. This study aimed to investigate the correlation of serum levels of apolipoprotein B 48, interleukin-1β and Homocysteine with BMI in patients with ischemic stroke (IS).
Over one hundred controls (120) and an equal number of IS patients, including 31 women and 89 men, were recruited to participate in the case-control study conducted at Imam Reza Hospital (Tabriz, Iran) from February 2019 to March 2020. We measured serum levels of apolipoprotein B 48, interleukin-1β, and Homocysteine. Receiver operating characteristic analysis (ROC) was performed to evaluate the diagnostic value of these indices in patients and control groups.
The mean serum levels of apolipoprotein B 48, interleukin-1β, and Homocysteine, were significantly increased in the experimental group compared to the control group with a p-value of 0.001. The ROC curve analysis showed that the area under the curve for apo B48, IL -1β, hs-CRP, and Homocysteine serum levels were 0.94, 0.98, 0.99, and 1, respectively.
The results of our current study show that the determination of serum levels of apolipoprotein B 48, interleukin-1β, and Homocysteine can potentially be used to monitor and diagnose IS patients. However, there was no statistically significant correlation between serum levels of apolipoprotein B 48, interleukin 1β and Homocysteine and BMI in the patient group. However, there was a statistically significant inverse correlation between serum levels of high-sensitivity C-reactive protein (hs-CRP) and BMI in the patient group.
中风是全球第二大致死原因，具有异质性特征。中风的亚型归因于不同的病理生理调节和病因。本研究旨在探讨缺血性中风（IS）患者血清载脂蛋白B 48、白细胞介素-1β和同型半胱氨酸水平与体重指数（BMI）之间的相关性。
2019年2月至2020年3月，在伊朗大不里士的伊玛目礼萨医院进行了一项病例对照研究，招募了一百多名对照者（120名）和数量相等的IS患者，其中包括31名女性和89名男性。我们测量了血清载脂蛋白B 48、白细胞介素-1β和同型半胱氨酸水平。采用受试者工作特征分析（ROC）来评估这些指标在患者组和对照组中的诊断价值。
与对照组相比，实验组血清载脂蛋白B 48、白细胞介素-1β和同型半胱氨酸的平均水平显著升高，p值为0.001。ROC曲线分析表明，载脂蛋白B48、白细胞介素-1β、高敏C反应蛋白（hs-CRP）和同型半胱氨酸血清水平的曲线下面积分别为0.94、0.98、0.99和1。
我们目前的研究结果表明，测定血清载脂蛋白B 48、白细胞介素-1β和同型半胱氨酸水平可能有助于监测和诊断IS患者。然而，患者组中血清载脂蛋白B 48、白细胞介素1β和同型半胱氨酸水平与BMI之间无统计学显著相关性。不过，患者组中血清高敏C反应蛋白（hs-CRP）水平与BMI之间存在统计学显著负相关。
