College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, 8 Daxue Road, Yichang 443002, Hubei, China.
Molecules. 2019 Sep 2;24(17):3191. doi: 10.3390/molecules24173191.
Diazo compounds have proven to be a useful class of carbenes or metal carbenoids sources under thermal, photochemical, or metal-catalyzed conditions, which can subsequently undergo a wide range of synthetically important transformations. Recently, asymmetric photocatalysis has provoked increasing research interests, and great advances have been made in this discipline towards the synthesis of optically enriched compounds. In this context, the past two decades have been the most productive period in the developments of enantioselective photochemical reactions of diazo compounds due to a better understanding of the reactivities of diazo compounds and the emergence of new catalytic modes, as well as easier access to and treatment of stabilized diazo compounds. This review highlights these impressive achievements according to the reaction type, and the general mechanisms and stereochemical inductions are briefly discussed as well.
重氮化合物已被证明是一类在热、光化学或金属催化条件下有用的卡宾或金属卡宾源，可随后进行广泛的具有重要合成意义的转化。最近，不对称光催化引起了越来越多的研究兴趣，在该领域中，在合成光学活性化合物方面取得了重大进展。在这种情况下，由于对重氮化合物的反应性有了更好的理解，以及新催化模式的出现，以及更容易获得和处理稳定的重氮化合物，过去二十年是重氮化合物对映选择性光化学反应发展最为活跃的时期。根据反应类型，本文重点介绍了这些令人印象深刻的成就，并简要讨论了一般的反应机制和立体化学诱导。
